Center for Systems Biology and Molecular Medicine

An ICMR collaborating centre of excellence (ICMR-CCoE)

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Biography

Prashant Kumar Modi

Ph.D.

Associate Professor

Dr. Prashant Kumar Modi obtained his Ph.D. from Banaras Hindu University. During this period he studied the effects of aging on glial cells with special emphasis on the astrocytes of the mice brain. During his post-doctoral training at Dr. Pushkar Sharma‘s laboratory, National Institute of Immunology, New Delhi, he worked on delineating the molecular mechanisms involved in cell cycle related neuronal apoptosis in Alzheimer‘s disease. He has been a recipient of DBT Research Associateship during 2011-2015 from Department of Biotechnology, Govt. of India. Currently, he is involved in the identification of biomarkers and novel therapeutic targets in neurodegenerative diseases such as Parkinson‘s disease and Alzheimer‘s disease using cutting-edge technologies in genomics, proteomics and metabolomics.

 

 

 




Publications

1.

Singh I, Anagha A, Kotimoole CN, Modi PK, Prasad TSK, Hoti SL. Unpacking immune modulation as a site of therapeutics innovation for nematode parasite Wuchereria bancrofti. 2024.

[DOI]


2.

Mahin A, Soman SP, Modi PK, Raju R, Keshava Prasad TS, Abhinand CS. Meta-analysis of the serum/plasma proteome identifies significant associations between COVID-19 with Alzheimer’s/Parkinson’s diseases. Journal of neurovirology. 2024;

[DOI]


3.

Kunnath AN, Parker SK, Crasta DN, Kunhiraman JP, Madhvacharya VV, Kumari S, Nayak G, Lakshmi RV, Modi PK, Prasad TS, Kumar A. Metformin augments major cytoplasmic organization except for spindle organization in oocytes cultured under hyperglycemic and hyperlipidemic conditions: An in vitro study. Toxicology and Applied Pharmacology. 2024

[DOI]


4.

Hegde A, Upadhyay SS, Prasad TS, Modi PK. Mass spectrometry–based approaches for the identification of molecular mechanism of action of ayurvedic medicines in Parkinson disease. InAyurvedic Herbal Preparations in Neurological Disorders 2023;

[DOI]


5.

Dasgupta M, Kumaresan A, Saraf KK, Nag P, Sinha MK, Aslam MK M, Karthikkeyan G, Prasad TK, Modi PK, Datta TK, Ramesha K. Deep metabolomic profiling reveals alterations in fatty acid synthesis and ketone body degradations in spermatozoa and seminal plasma of astheno-oligozoospermic bulls. Frontiers in Veterinary Science. 2022;

[DOI]


6.

Behera SK, Modi PK, Karthikkeyan G, Pervaje SK, Pervaje R, Raju R, Prasad TS, Subbannayya Y. From LC-MS/MS metabolomics profiling of Kanchanara Guggulu to molecular docking and dynamics simulation of quercetin pentaacetate with aldose reductase. Bioinformation. 2021;

[DOI]


7.

DasGupta M, Kumaresan A, Saraf KK, Paul N, Sajeevkumar T, Karthikkeyan G, Prasad TK, Modi PK, Ramesha K, Manimaran A, Jeyakumar S. Deciphering metabolomic alterations in seminal plasma of crossbred (Bos taurus X Bos indicus) bulls through comparative deep metabolomic analysis. Andrologia. 2022;

[DOI]


8.

Najar MA, Aravind A, Dagamajalu S, Sidransky D, Ashktorab H, Smoot DT, Gowda H, Prasad TK, Modi PK, Chatterjee A. Hyperactivation of MEK/ERK pathway by Ca2+/calmodulin‐dependent protein kinase kinase 2 promotes cellular proliferation by activating cyclin‐dependent kinases and minichromosome maintenance protein in gastric cancer cells. Molecular Carcinogenesis. 2021;

[DOI]


9.

Kalal BS, Modi PK, Upadhya D, Saha P, Prasad TS, Pai VR. Inhibition of bone morphogenetic proteins signaling suppresses metastasis melanoma: a proteomics approach. American journal of translational research. 2021;

[PubMed]


10.

Rex DA, Arun Kumar ST, Modi PK, Keshava Prasad TS. Broadening COVID-19 Interventions to Drug innovation: neprilysin pathway as a friend, foe, or promising molecular target?. OMICS: A Journal of Integrative Biology. 2021 Jul 1;25(7):408-16.

[DOI]


11.

Rex DA, Arun Kumar ST, Rai AB, Kotimoole CN, Modi PK, Prasad TS. Novel post-translational modifications and molecular substrates in glioma identified by bioinformatics. OMICS: A Journal of Integrative Biology. 2021 Jul 1;25(7):463-73.

[DOI]


12.

Najar MA, Rex DA, Modi PK, Agarwal N, Dagamajalu S, Karthikkeyan G, Vijayakumar M, Chatterjee A, Sankar U, Prasad TK. A complete map of the Calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) signaling pathway. Journal of cell communication and signaling. 2021 Jun;15(2):283-90.

[DOI]


13.

Dagamajalu S, Rex DA, Gopalakrishnan L, Karthikkeyan G, Gurtoo S, Modi PK, Mohanty V, Mujeeburahiman M, Soman S, Raju R, Tiwari V. A network map of endothelin mediated signaling pathway. Journal of Cell Communication and Signaling. 2021 Jun;15(2):277-82.

[DOI]


14.

Najar MA, Modi PK, Ramesh P, Sidransky D, Gowda H, Prasad TK, Chatterjee A. Molecular profiling associated with calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2)-mediated carcinogenesis in gastric cancer. Journal of proteome research. 2021 Apr 12;20(5):2687-703.

[DOI]


15.

Shaikh SB, Najar MA, Prabhu A, Rex DA, Chanderasekaran J, Behera SK, Modi PK, Prasad TS, Bhandary YP. The unique molecular targets associated antioxidant and antifibrotic activity of curcumin in in vitro model of acute lung injury: A proteomic approach. BioFactors. 2021 Jul;47(4):627-44.

[DOI]


16.

Karthikkeyan G, Pervaje R, Pervaje SK, Prasad TS, Modi PK. Prevention of MEK-ERK-1/2 hyper-activation underlines the neuroprotective effect of Glycyrrhiza glabra L.(Yashtimadhu) against rotenone-induced cellular and molecular aberrations. Journal of ethnopharmacology. 2021 Jun 28;274:114025.

[DOI]


17.

Shaikh SB, Najar MA, Prabhu A, Rex DA, Chanderasekaran J, Behera SK, Modi PK, Prasad TS, Bhandary YP. The unique molecular targets associated antioxidant and antifibrotic activity of curcumin in in vitro model of acute lung injury: A proteomic approach. BioFactors. 2021 Jul;47(4):627-44.

[DOI]


18.

DasGupta M, Kumaresan A, Saraf KK, Karthikkeyan G, Prasad TK, Modi PK, Ramesha K, Jeyakumar S, Manimaran A. Preliminary comparative deep metabolomic analysis of spermatozoa from zebu and crossbred cattle suggests associations between metabolites, sperm quality and fertility. Reproduction, Fertility and Development. 2021 Apr 1;33(6):427-36.

[DOI]


19.

Shaikh S, Bhandary YP, Najar MA, Prabhu A, Prasad TK, Gouda MM, Irfan K, Modi PK. In depth mass spectrometry based proteomic approach to explore the effect of curcumin in IL17A mediated alveolar barrier injury.

[DOI]


20.

Najar MA, Rex DA, Modi PK, Agarwal N, Dagamajalu S, Karthikkeyan G, Vijayakumar M, Chatterjee A, Sankar U, Prasad TK. A complete map of the Calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) signaling pathway. Journal of cell communication and signaling. 2021 Jun;15(2):283-90.

[DOI]


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