Center for Systems Biology and Molecular Medicine

An ICMR collaborating centre of excellence (ICMR-CCoE)

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Biography

T. S. Keshava Prasad

Ph.D.

Professor and Deputy Director

Dr. T. S. Keshava Prasad is a recipient of Young Investigator Award from the Department of Biotechnology, Government of India. He is leading IOB's efforts on the development of the Human Protein Reference Database, which is cited over 2000 times. In addition, he has successfully completed a DBT funded research project on proteomic profiling of esophageal squamous cell carcinoma in collaboration with Kidwai Memorial Institute of Oncology, Bangalore. His research group is now increasingly focusing on infectious diseases, human pathogens and vectors of human diseases. He is funded by DST, Government of India to develop an epitope based diagnostic gadget for the detection of tuberculosis in Indian population.




Publications

1.


Varughese A, Balnadupete A, Ramesh P, Prasad TSK, Nidha AB, Bhandary Y. Guardians turned culprits: NETosis and its influence on pulmonary fibrosis development. Molecular Biotechnology. 2025;67(5):1752–64.

[DOI]


2.

Upadhyay SS, Shetty R, Prasad TSK. Prospects for the discovery of actionable molecular targets for triple negative breast cancer. In: Book Chapter; 2025.

In press


3.

Suchitha GP, Upadhyay SS, Pervaje R, Prasad TSK, Dagamajalu S. Uncovering the anticancer effects of Bhallataka Taila in lung cancer: a metabolomic and network pharmacology approach. BioImpacts. 2025;15(30568). 

[DOI]


4.

Suchitha GP, Upadhyay SS, Pervaje R, Prasad TSK, Dagamajalu S. Uncovering the anticancer effects of Bhallataka Taila in lung cancer: a metabolomic and network pharmacology approach. BioImpacts. 2025;15(30568).

[DOI]


5.

Suchitha GP, Rai AB, Pervaje R, Kotimoole CN, Modi PK, Prasad TSK, et al. Proteomic analysis reveals anticancer mechanisms of Bhallataka Taila in inhibiting lung cancer progression and metastasis. Molecular Omics. 2025;21(2):122–34.

[DOI]


6.

Suchitha GP, Rai AB, Pervaje R, Kotimoole CN, Modi PK, Prasad TSK, et al. Proteomic analysis reveals anticancer mechanisms of Bhallataka Taila in inhibiting lung cancer progression and metastasis. Molecular Omics. 2025;21(2):122–34.

[DOI]


7.

Sreelakshmi K, Hemavathi KN, Raju R, Sameer K, Prasad TSK, Sudhakaran PR, et al. Identification and stability analysis of potential ADP‐ribose modification sites on vascular endothelial growth factor (VEGF) through molecular dynamics simulation. Journal of Biomolecular Structure and Dynamics. 2025;43(7):3406–14. 

[DOI]


8.

Shastry RP, Hameed A, Banerjee S, Prabhu A, Bajire SK, Pavan B SR, et al. Tryptic oncopeptide secreted from the gut bacterium Cronobacter malonaticus PO3 promotes colorectal cancer. Scientific Reports. 2025; 

[DOI]


9.

Shaji V, Amrutha S, Pervaje R, Abhinand CS, Raju R, Prasad TSK, et al. Exploration of Asparagus racemosus Willd for Alzheimer’s Disease Through Integrated Metabolomics and Network Pharmacology Analyses Targeting BACE1 Protein. Neurochemical Research. 2025;50(3). 

[DOI]


10.

Sarma A, Phukan H, Rex DAB, Thoduvayil S, Dhandapani G, Christie S, et al. Exoproteome profiling reveals increased secretion of adhesins and proteases by Leptospira interrogans to facilitate host colonization and immune modulation. ACS Omega. 2025; 

[DOI]


11.

Sarma A, Phukan H, Rex DAB, Thoduvayil S, Dhandapani G, Christie S, et al. Exoproteome Profiling Reveals Increased Secretion of Adhesins and Proteases by Leptospira interrogans to Facilitate Host Colonization and Immune Modulation. ACS Omega. 2025; 

In press


12.

Roy O, Ammankallu S, Narayana VK, Narayana C, Hebbar S, Adiga PK, et al. Mass Spectrometric Analysis of Clomiphene Citrate‐induced Changes in the Secretome Profile of PAX8‐positive Human Fallopian Tube Secretory Epithelial Cells and Identification of Biomarkers Relevant to Reproduction and Pregnancy. Reproductive Sciences. 2025:1–19. 

[DOI]


13.

Rex DAB, Prasad TSK. Data analysis pipelines, potential pitfalls, and troubleshooting for MS‐based biomarker discovery and validation. In: Book Chapter; 2025.

In press


14.

Rawat A, Antil N, Meenakshi D, B R, AB N, A S, et al. PfPPM2 signalling regulates asexual division and sexual conversion of human malaria parasite Plasmodium falciparum. Nature Communications. 2025;16(1).

In press


15.

Ramesh P, Akbar KCJ, Prasad TSK. Protein biomarkers for diagnosing gastric cancers. In: Book Chapter; 2025.

In press


16.

Rai AB, Codi JAK, Suchitha GP, Hemavathi KN, Dagamajalu S, Abhinand CS. Mapping growth differentiation factor‐15 (GDF15)‐mediated signaling pathways in cancer: insights into its role across different cancer types. Discover Oncology. 2025;16(1):1–15. 

[DOI]


17.

Rai AB, Codi JAK, Kotimoole CN, Ramesh P, Narayana VK, Shaji V, et al. Data‐Independent Acquisition Analysis to Identify Serum Biomarkers and Neoantigens for Differentiating Colorectal Cancer from Inflammatory Bowel Diseases. Journal of Proteome Research. 2025; 

[DOI]


18.

Poojary KK, Kunhiraman JP, Madhvacharya K VV, S K, N SSP, Kalthur G. Bromodomain and extraterminal protein inhibitor JQ1 induces maturation arrest and disrupts the cytoplasmic organization in mouse oocytes under in vitro conditions. Scientific Reports. 2025;15(1). 

[DOI]


19.

Parate SS, Vijayakumar M, Prasad TSK. Ex vivo drug assay as a potential hospital‐based testing platform for clinical research and personalized treatment for solid tumors. In: Book Chapter; 2025.

In press


20.

Palollathil A, Dagamajalu S, Ahmed M, Vijayakumar M, Prasad TSK, Raju R. The network map of mucin 1 mediated signaling in cancer progression and immune modulation. Discover Oncology. 2025;16(1):1–15. 

[DOI]


21.

Nisar M, Soman SP, Sreelan S, John L, Pinto SM, Kandasamy RK, et al. ProteoArk: A One‐Pot Proteomics Data Analysis and Visualization Tool for Biologists. Journal of Proteome Research. 2025;24(3):1008–16. 

[DOI]


22.

Nisar M, Soman SP, Sreelan S, John L, Pinto SM, Kandasamy RK, et al. ProteoArk: a one‐pot proteomics data analysis and visualization tool for biologists. Journal of Proteome Research. 2025;24(3):1008–16. 

[DOI]


23.

Nekrakalaya B, Kotimoole CN, Arefian M, Prasad TSK, Palliyath GK, Hanumanthappa PV, et al. A Gel‐Free Genome Annotation Provides Insights into the Proteome of the Oomycete Phytophthora meadii, a Disease‐Causing Pathogen in Economically Important Crops. OMICS: A Journal of Integrative Biology. 2025;

[DOI]


24.

Mallick S, Narayana VK, Rai AB, Upadhyay SS, Prasad TSK, Shenoy S, et al. Hematopoietic stem cell conditioned media induces apoptosis in colorectal cancer stem cells via dysregulation of HSP90 and 26S proteasome system. International Journal of Biochemistry & Cell Biology. 2025;184(106773). 

[DOI]


25.

Mahin A, Gopalakrishnan AP, Ahmed M, Nisar M, John L, Shivamurthy PB, et al. Orchestrating Intracellular Calcium Signaling Cascades by Phosphosite‐Centric Regulatory Network: A Comprehensive Analysis on Kinases CAMKK1 and CAMKK2. OMICS: A Journal of Integrative Biology. 2024;29(4):139–53.

[DOI]


26.

Mahin A, Gopalakrishnan AP, Ahmed M, Nisar M, John L, Shivamurthy PB, et al. Orchestrating intracellular calcium signaling cascades by phosphosite-centric regulatory network: a comprehensive analysis on kinases CAMKK1 and CAMKK2. OMICS: A Journal of Integrative Biology. 2024;29(4):139–53. 

[DOI]


27.

Mahadevaswamy M, Suchitha GP, Pavan V SR, HK N, SD C, S S, et al. Naringin attenuates angiotensin II induced cardiac hypertrophy by inhibiting carbonic anhydrase II. Scientific Reports. 2025;15(1). 

[DOI]


28.

Krishna RM, Maruthakasi S, Arulappan J, Raghava LK, Abdulla SA, Budhwar R, et al. The Genome Sequence of the Rugose Spiraling Whitefly (Aleurodicus rugioperculatus Martin): Insights on Biology of an Invasive Agricultural Insect Pest and Implications for Pest Control. OMICS: A Journal of Integrative Biology. 2025;

[DOI]


29.

Kapoor A, Meitei NS, Bisht VS, Najar MA, Giri K, Prasad TSK, et al. Lactation stage‐specific variations in health and lipid‐associated milk fat globule membrane proteins in Holstein Friesian cow and Murrah buffalo. International Dairy Journal. 2025; 

[DOI]


30.

Kapoor A, Meitei NS, Bisht VS, Najar MA, Giri K, Prasad TSK, et al. Lactation stage‐specific variations in health and lipid‐associated milk fat globule membrane proteins in Holstein Friesian cow and Murrah buffalo. International Dairy Journal. 2025; 

[DOI]


31.

Bisht VS, Kumar D, Najar MA, Giri K, Kaur J, Prasad TSK, et al. Drug response‐based precision therapeutic selection for tamoxifen‐resistant triple‐positive breast cancer. Journal of Proteomics. 2025;

[DOI]


32.

Bisht VS, Kumar D, Najar MA, Giri K, Kaur J, Prasad TSK, et al. Drug response‐based precision therapeutic selection for tamoxifen‐resistant triple‐positive breast cancer. Journal of Proteomics. 2025;310(105319). 

[DOI]


33.

Bhat S, Narayana VK, Prasad TSK. Metabolomics studies in Cushing’s syndrome: recent developments and perspectives. Expert Review of Proteomics. 2025;22(2):59–69. 

[DOI]


34.

Bhat S, Narayana VK, Prasad TSK. Metabolomics studies in Cushing’s syndrome: recent developments and perspectives. Expert Review of Proteomics. Taylor & Francis Online; 2025; 

[DOI]


35.

Banjan B, Raju R, Prasad TSK, Abhinand CS. Computational identification of potential bioactive compounds from Triphala against alcoholic liver injury by targeting alcohol dehydrogenase. Molecular Diversity. 2025;29(1):623–38.

[DOI]


36.

Banjan B, Raju R, Prasad TSK, Abhinand CS. Computational identification of potential bioactive compounds from Triphala against alcoholic liver injury by targeting alcohol dehydrogenase. Molecular Diversity. 2025;29(1):623–38. 

[DOI]


37.

Aravind A, Shaji V, Ahmed M, Dagamajalu S, Vijayakumar M, Prasad TSK, et al. An assembled molecular signaling map of interleukin‐24: a resource to decipher its multifunctional immunoregulatory role in pathophysiological conditions. Frontiers in Immunology. 2025;16(1608101). 

[DOI]


38.

Ananthakrishnan AI, Mahin A, Prasad TSK, Abhinand CS. Transcriptome Profiling and Viral–Human Interactome Insights into HBV‐Driven Oncogenic Alterations in Hepatocellular Carcinoma. Microbiology and Immunology. 2025; 

In press


39.

Amrutha S, Abhinand CS, Upadhyay SS, Pervaje R, Prasad TSK, Modi PK. Network pharmacology and metabolomics analysis of Tinospora cordifolia reveals BACE1 and MAOB as potential therapeutic targets for neuroprotection in Alzheimer’s disease. Scientific Reports. 2025;15(8103).

[DOI]


40.

Amrutha S, Abhinand CS, Upadhyay SS, Pervaje R, Prasad TSK, Modi PK. Network pharmacology and metabolomics analysis of Tinospora cordifolia reveals BACE1 and MAOB as potential therapeutic targets for neuroprotection in Alzheimer’s disease. Scientific Reports. 2025; 

[DOI]


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