Center for Systems Biology and Molecular Medicine
An ICMR collaborating centre of excellence (ICMR-CCoE)
Biography
Mohammad Altaf Najar
Ph.D.
Assistant Professor
Dr. Mohd Altaf Najar completed his Ph.D. at the Yenepoya Research Centre, Yenepoya (Deemed to be University), Mangalore, where his doctoral research focused on understanding cancer-associated signaling networks using mass spectrometry-based proteomics and phosphoproteomics. During his Ph.D., he carried out indepth mechanistic studies on Calcium/Calmodulin Dependent Protein Kinase Kinase 2 (CAMKK2), elucidating its role in cancer progression through large scale proteomic and phosphoproteomic profiling. His work provided important insights into CAMKK2 driven signaling pathways and their implications in tumor biology.
Following his Ph.D., Dr. Najar moved to the University of Pennsylvania (UPenn), USA, to pursue postdoctoral research. At UPenn, his research focused on investigating the role of protein acetylation in regulating protein turnover and cellular homeostasis, with particular emphasis on posttranslational modification mediated control of protein stability. His postdoctoral work combined advanced proteomics, biochemical approaches, and systems level analyses to dissect how acetylation influences protein degradation pathways and cellular function.
Dr. Najar has now joined the Yenepoya Research Centre, Yenepoya (Deemed to be University) as an Assistant Professor (Stage II). His current research program aims to explore the role of deubiquitinases (DUBs) across multiple cancer types, with a focus on understanding how ubiquitin mediated signaling and protein quality control contribute to cancer initiation, progression, and therapeutic resistance. By integrating quantitative proteomics, functional assays, and computational analysis, his lab seeks to identify novel regulatory mechanisms and potential therapeutic vulnerabilities in cancer.
Dr. Najar has authored several peer reviewed research articles in high quality international journals, reflecting the impact of his work in cancer signaling and proteomics. His doctoral research resulted in publications in well regarded journals such as the Journal of Proteome Research and Molecular Carcinogenesis, highlighting rigorous mechanistic and systems level analyses. During his postdoctoral tenure at the University of Pennsylvania, his research contributed to publications in top-tier journals, including Science, Nature Chemical Biology, Cell Reports, and Nature Communications, underscoring his involvement in cutting edge discoveries in protein regulation and post-translational modification biology. A complete list of his publications and citation metrics is available on his Google Scholar profile: https://scholar.google.com/citations?user=SaC2bZUAAAAJ&hl=en&authuser=1
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