Center for Systems Biology and Molecular Medicine

Center for Systems Biology and Molecular Medicine

CSBMM
Mohan B Appaiahgari, Ph.D.

Associate Professor


Biography

Dr. Mohan B Appaiahgari is a Virologist by education and research training. He obtained master’s degree in virology from Sri Venkateswara University, Tirupati, and doctoral degree in virology-cum-biotechnology from Jamia Hamdard, New Delhi. He has strong inclination for translational research and his notable achievements include identification of potential biomarkers, development of novel vaccine candidates having commercialization potential, identification of novel antiviral therapeutic candidates, clinical development of a human vaccine, etc. Besides, he has ongoing interests in basic, translational and diagnostic virology. Post-Ph.D., he briefly worked as an awardee at THSTI, Faridabad, and later joined as Faculty Scientist. He published in various international journals and also has patents to his credit. In 2018, he founded a startup and pursued a BIRAC-funded project on the development of a novel poultry vaccine, wherein its superiority over existing vaccine is successfully established. Recently, through collaborative efforts, they identified novel drug targets in SARS-CoV-2 replication. Dr. Mohan B Appaiahgari received the Vaccine Research Innovation (VRI) award from DBT for the year 2008 to carry out post-doctoral research in translational sciences at THSTI, Faridabad. He worked as VRI awardee between October 2008 and November 2009, during which time he conceived a project on the development of novel animal adenovirus-based gene/vaccine delivery vector systems for potential human and animal use. As part of this, he has isolated several novel animal adenoviruses from a variety of animal species. Later, he also received a DBT-funded grant for their characterization and currently he is pursuing the same to explore the vectorial properties of these novel animal adenoviruses.

Research Interest/Area
  • Understanding virus biology and immunology
  • Novel antiviral drug-discovery
  • Biomarker identification for future translation
  • Development of novel viral and non-viral gene/vaccine delivery systems
  • Development of novel POC-compatible molecular diagnostic systems
  • Education
  • Ph.D. in Biotechnology/Virology, Jamia Hamdard, New Delhi, India, 2017
  • M.Sc. in Virology, Sri Venkateswara University, Tirupati, India, 2010
  • Honors and Awards
    • Received Vaccine Research Innovation (VRI) award for the year 2008 from DBT to carry out post-doctoral research in translational sciences at THSTI, Faridabad.
    • Australian patent application (AU2005315143), 2007. DNAzymes for inhibition of Japanese Encephalitis virus replication. Inventors: Vrati S & Appaiahgari MB. Status: Granted on 8th Sep, 2011
    • Singapore patent application # 133150. DNAzymes for inhibition of Japanese Encephalitis virus replication. Inventors: Vrati S & Appaiahgari MB. Status: Granted on 30th April 2012
    • Indian Patent Application (# 202241040123 priority date 13.07.2022). Vaccine composition and method of preparation thereof. Inventors: Appaiahgari MB & Kayampeta SR. Applicant: Srikara Biologicals Private Limited, Tirupati. Status: Filed
    • PCT Application (# PCT/IN2023/050680 dated 12.07.2023). Vaccine composition and method of preparation thereof. Inventors: Appaiahgari MB & Kayampeta SR. Applicant: Srikara Biologicals Private Limited, Tirupati. Status: Published on 18th Jan, 2024
    Publications

    Research papers:14; Review articles: 0; Book Chapters: 1

    • Trivedi A et.al.* (2023), Identification of a novel inhibitor of Coronavirus-Main Protease: An in-silico, biochemical and cell-based approach. FEBS J. In press.
    • Kulandaisamy R et.al. (2022), Repurposing of FDA-approved drugs against SARS-CoV-2 Papain-Like protease: Computational, Biochemical and in vitro Studies. Front. Microbiol. . 1-10. [PubMed]