Center for Systems Biology and Molecular Medicine

Center for Systems Biology and Molecular Medicine

CSBMM

Biography

Dr. Abhinand C. S., obtained his PhD in Computational Biology and Bioinformatics from the Department of Computational Biology and Bioinformatics, University of Kerala in 2017. Later on, he moved to Japan and did his postdoctoral research at the Institute of Advanced Biosciences, Keio University. In 2019, he re-joined at the Department of Computational Biology and Bioinformatics, University of Kerala as a DBT-BIF fellow and started working on computational studies related with viral infectious diseases and therapy. He also was interested in and worked on the COVID-19 based drug design studies while working as a Scientist in the University of Kerala. He is currently working as an Assistant Professor at the Center for Systems Biology and Molecular Medicine (CSBMM), Yenepoya Research Center, Yenepoya (Deemed to be University) where he is focused on conducting bioinformatics studies related to multiomics data.

Research Interest/Area

Modeling biological signal transduction pathways

Development of databases and Bioinformatics tools

Computer aided drug designing

Peptide drug designing

Multiomics data analysis

Education

Ph.D. in Computational Biology and Bioinformatics, India, 2017

M.phil. in Bioinformatics, India, 2012

M.Sc. in Bioinformatics, India, 2010

Positions held

Scientist, Department of Computational Biology & Bioinformatics, University of Kerala, India, 2020-2022
DBT-BIF Fellow, Department of Computational Biology & Bioinformatics, University of Kerala, India, 2019-2020
Postdoctoral Fellow, Keio Institute for Advanced Biosciences, Tsuruoka, Japan, 2018

Honors and Awards

Special Invitee, Board of studies in Computational Biology & Bioinformatics, University of Kerala, 2020
Kuraray/Leave a Nest Grant Runner-up award, Grant value 200,000 Yen, 2017
SIUCEB Travel Grant award for ICSB 2015, Singapore, 2015
VirginiaTech International Travel Grant for “COPASI User Workshop 2014” held at Washington DC, USA, 2014
Best poster award in the International Conference on “Tropical Roots and Tubers for Sustainable Livelihood under Changing Agro-climate”, 2013
Research fellowship award by Kerala State Council for Science Technology and Environment covering both living and research expenses for the Ph.D. course, 2012

Publications

Research papers:14; Review articles: 0; Book Chapters: 1

Soumya S. J., Abhinand C. S., Arya S. Nair, Sonu P. S., Achuthshankar S. Nair, G. M. Nair, A. Gangaprasad, and Jayakumaran Nair A. "Chrysin Inhibits Adipogenesis by Modulating PPARγ: In Silico and In Vitro Studies. Journal of Biomolecular Structure & Dynamics. In press.

Shastry, R. P. and Abhinand, C. S. (2023). Targeting the Pseudomonas aeruginosa quorum sensing system to inhibit virulence factors and eradicate biofilm formation using AHL-analogue phytochemicals. Journal of Biomolecular Structure and Dynamics. 1-10. [PubMed]

Abhinand, C. S., Galipon, J., Mori, M., Ramesh, P., Prasad, T. S. K., Raju, R., Sudhakaran, P.R. and Tomita, M. (2023). Temporal phosphoproteomic analysis of VEGF-A signaling in HUVECs: an insight into early signaling events associated with angiogenesis. Journal of Cell Communication and Signaling. 1-13.[PubMed]

Abhinand, C. S., Athira, P., Krishnamurthy, A., Raju, R., Prasad, T. S. K., Nair, A. S., Rajasekharan, K. N., Oommen, O. V. and Sudhakaran, P. R. (2022). SARS-CoV-2 variants infectivity prediction and therapeutic peptide design using computational approaches. Journal of Biomolecular Structure & Dynamics. In Press.

Abhinand, C. S., Ibrahim, J. M., Prasad, T. S. K., Raju, R., Oommen, O. V. and Nair, A. S. (2022). Molecular docking and dynamics studies for the identification of Nipah virus glycoprotein inhibitors from Indian medicinal plants. Journal of Biomolecular Structure & Dynamics. [PubMed]

Arya, K. R., Bharath Chand, R. P., Abhinand, C. S., Nair, A. S., Oommen, O. V., & Sudhakaran, P. R. (2021). Identification of Hub Genes and Key Pathways Associated with Anti-VEGF Resistant Glioblastoma Using Gene Expression Data Analysis. Biomolecules. 11, 403.

Abhinand, C. S., Nair, A. S., Krishnamurthy, A., Oommen, O. V., & Sudhakaran, P. R. (2022). Potential protease inhibitors and their combinations to block SARS-CoV-2. Journal of Biomolecular Structure and Dynamics. 40, 903-917.

Abhinand, C. S., Athira, P. A., Soumya, S. J., & Sudhakaran, P. R. (2020). Multiple targets directed multiple ligands: An in silico and in vitro approach to evaluating the effect of triphala on angiogenesis. Biomolecules. 10, 177.

Sunitha, P., Raju, R., Sajil, C. K., Abhinand, C. S., Nair, A. S., Oommen, O. V., ... & Sudhakaran, P. R. (2019). Temporal VEGFA responsive genes in HUVECs: Gene signatures and potential ligands/receptors fine-tuning angiogenesis. Journal of cell communication and signaling. 13, 561-571.

Sudhakar, M., Silambanan, S., Chandran, A. S., Prabhakaran, A. A., & Ramakrishnan, R. (2018). C-reactive protein (CRP) and leptin receptor in obesity: binding of monomeric CRP to leptin receptor. Frontiers in immunology. 9, 1167.

Athira, A. P., Abhinand, C. S., Saja, K., Helen, A., Reddanna, P., & Sudhakaran, P. R. (2017). Anti-angiogenic effect of chebulagic acid involves inhibition of the VEGFR2-and GSK-3β-dependent signaling pathways. Biochemistry and Cell Biology. 95, 563-570.

Abhinand, C. S., Raju, R., Soumya, S. J., Arya, P. S., & Sudhakaran, P. R. (2016). VEGF-A/VEGFR2 signaling network in endothelial cells relevant to angiogenesis. Journal of cell communication and signaling. 10, 347-354.

Santhosh Mithra, V.S. and Abhinand, C. S. (2015) Fuzzy algorithm to decompose combinational conditions and conclusions in fuzzy systems. IRJCS. 2, 14-30.

Santhosh Mithra, V.S., Abhinand, C. S. and Sreekumar, J. (2014) Horoscope algorithm to predict potential yield of cassava. World App.Sci.J. 30, 341-344.

Santhosh Mithra, V.S., James George, Abhinand, C. S. and Sreekumar, J. (2014) E-networking of All India Coordinated Research Project on Tuber Crops. J. Root Crops. 40, 105-110