Center for Systems Biology and Molecular Medicine

Center for Systems Biology and Molecular Medicine

CSBMM
Aditi Chatterjee, Ph.D.

Professor and Associate Director


Biography

Dr. Aditi Chatterjee has investigated the role of cigarette smoke in the induction of chemotherapeutic resistance in bladder cancer using miRNA profiling approaches. She has also studied mitochondrial damage and repair in various cancers to decipher molecular mechanisms involved in DNA repair. She is the Senior Guest Editor for the Journal of Oncology for a special issue on Cigarette Smoke and Cancer. She has been a reviewer for PLOS One, Journal of Proteomics, FEBS Letters and Hematological Oncology. Currently, she is carrying out whole genome sequencing and phosphoproteomic profiling of gallbladder cancer. She is also studying the effect of cigarette smoke on progression of oral cancer and its related chemoresistance. Her other projects involve studying the role of miRNA in cancer with relation to cigarette smoke.

Scientific discipline
  • Signaling alterations in head & neck and lung cancer
  • Cancer Biology/Molecular Biology
  • Signaling pathway
  • miRNA in cancer
  • Proteomics
    • Education
  • Ph.D. in Biochemistry, University College of Science, Department of Biochemistry, Calcutta, India, 2001
  • M.Sc. in Biochemistry, University College of Science, Department of Biochemistry, Calcutta, India, 1995
    • Positions held
    • Professor and Associate Director, Center for Systems Biology and Molecular Medicine, Yenepoya University, Mangalore, India, June 2015 – present
    • Faculty Scientist, Institute of Bioinformatics, Bangalore, India, July 2011 – present
    • Instructor, Department of Otolaryngology, Johns Hopkins University, School of Medicine, Baltimore, MD, USA, April 2008 – June 2011
    • Senior Postdoctoral Research Fellow, Department of Otolaryngology, Johns Hopkins University, School of Medicine, Baltimore, MD, USA, February 2006 – March 2008
    • Postdoctoral Research Fellow, Department of Otolaryngology, Johns Hopkins University, School of Medicine, Baltimore, MD, USA, July 2002 – July 2005
    • Postdoctoral Research Fellow, Department of Oncology, Johns Hopkins University, School of Medicine, Baltimore, MD, USA, September 2000– June 2002
    • Summer Internship, University of Minnesota, Twin Cities, Saint Paul, MN, USA, August 1998 - May 1999
    • Graduate Student, Research fellow in Biochemistry, University of Calcutta, Department of Biochemistry, Calcutta, India, December 1995 –August 2000
    Honors and Awards
    • Receipient of “Bharat Ratna Mother Teresa Gold Medal Award” from the Global Economic Progress and Research Association for the year 2016 for her outstanding individual achievement in science and research
    • Recipient of 2007 Young Clinical Scientist Award from Flight Attendant Medical Research Institute
    • Judged as the best speaker at Young Scientists Symposium on Frontiers of Reproductive Biology, Hyderabad, India
    Publications
     

    Research papers: 62; Review articles: 2

     
    • Khan, A. A., Advani, J., Patel, K., Nanjappa, V., Datta, K. K., Solanki, H. S., Kumar, P., Mathur, P. P., Nair, B. P., Prasad, T. S. K., Chatterjee, A and Gowda, H. (2017). Chronic exposure of cigarette smoke and chewing tobacco alters expression of microRNAs in esophageal epithelial cells. MicroRNA. In Press.

    • Rajagopalan, P., Nanjappa, V., Patel, K., Jain, A. K., Mangalaparthi, K. K., Patil, A. H., Nair, B., Mathur, P. P., Prasad, T. S. K., Califano, J. A., Sidransky, D., Gowda, H. and Chatterjee, A. (2017). Role of protein kinase N2 (PKN2) in cigarette smoke-mediated oncogenic transformation of oral cells. Journal of Cell Communication and Signaling. In Press.

    • Advani, J., Subbannayya, Y., Gowda H. and Chatterjee, A. (2017). Bioinformatics advances to accelerate omics innovations and applications in the postgenomic era. OMICS: A Journal of Integrative Biology. [PubMed]

    • Nanjappa, V., Sathe, G.J., Jain, A. P., Rajagopalan, P., Raja, R, Subbannayya, T., Patil, A. H., Kumar, P., Prasad, T. S. K., Mathur, P. P., Sidransky, D., Gowda, H. and Chatterjee, A. Investigation of curcumin mediated signaling pathways in head and neck squamous cell carcinoma. Translational Research in Oral Oncology. In press

    • Solanki, H. S., Babu, N., Jain, A. P., Bhat, M. Y., Puttamallesh, V. N., Advani, J., Raja, R., Mangalaparthi, K. K., Kumar, M. M., Prasad, T. S. K., Mathur, P. P., Sidransky, D., Gowda, H. and Chatterjee, A. (2017). Cigarette smoke induces mitochondrial metabolic reprogramming in lung cells. Mitochondrion. In press

    • Advani, J.#, Subbannayya, Y.#, Patel, K., Khan, A. A., Patil, A. H., Jain, A. P., Solanki, H. S., Radhakrishnan, A., Pinto, S. M., Sahasrabuddhe, N. A., Thomas, J. K., Mathur, P. P., Nair, B., Chang, X., Prasad, T. S. K., Sidransky, D., Gowda H. and Chatterjee, A. (2017). Long term cigarette smoke exposure and changes in microRNA expression and proteome in non-small cell lung cancer. OMICS: A Journal of Integrative Biology. [PubMed] (# These authors contributed equally to the manuscript)

    • Mir, S. A., Pinto, S. M., Paul, S., Raja, R., Nanjappa, V., Syed, N., Advani, J., Renuse, S., ahasrabuddhe, N. A., Prasad, T. S. K., Giri, A. K., Gowda, H., and Chatterjee, A*. (2016). SILAC-based quantitative proteomic analysis reveals widespread molecular alterations in human skin keratinocytes upon chronic arsenic exposure. Proteomics. [Pubmed]
      • (*Corresponding author)

    • Radhakrishnan, A., Nanjappa, V., Raja, R., Sathe, G., Puttamallesh, V. N., Jain, A. P., Pinto, S. M., Balaji, S. A., Chavan, S., Sahasrabuddhe, N. A., Mathur, P. P., Kumar, M. M., Prasad, T. S. K., Santosh, V., Sukumar, G., Califano, J. A., Rangarajan, A., Sidransky, D., Pandey, A., Gowda, H. and Chatterjee, A*. (2016). A dual specificity kinase, DYRK1A, as a potential therapeutic target for head and neck squamous cell carcinoma. Scientific Reports. [PubMed] (*Corresponding author)

    • Raja, R., Sahasrabuddhe, N. A., Radhakrishnan, A., Syed, N., Solanki, H., Puttamallesh, V. N., Balaji, S. A., Nanjappa, V., Datta, K. K., Babu, N., Renuse, S. Patil, A. H, Izumchenko, E., Prasad, T. S. K., Chang, X., Rangarajan,A., Sidransky, D., Pandey, A., Gowda, H. and Chatterjee, A. (2016). Chronic exposure to cigarette smoke leads to activation of p21 (RAC1) - activated kinase 6 (PAK6) in non-small cell lung cancer cells. Oncotarget. [PubMed]

    • Yelamanchi S. D., Solanki, H. S., Radhakrishnan, A., Balakrishnan, L., Advani, J., Raja, R., Sahasrabuddhe, N. A., Mathur, P. P., Dutta, P., Prasad, T. S. K., Korbonits, M., Chatterjee, A., Gowda, H., Mukherjee, K. K. (2016). Signaling network map of aryl hydrocarbon receptor. Journal of Cell Communication and Signaling. 10, 341-346 [PubMed]

    • Sathe, G. J*., Pinto, S. M*., Syed, N., Nanjappa, V., Solanki, H. S., Renuse, S., Chavan, S., Khan, A. A., Patil, A. H., Nirujogi, R. S., Nair, B., Mathur, P. P., Prasad, T. S. K., Gowda, H and Chatterjee, A. (2016). Phosphotyrosine profiling of curcumin-induced signaling.Clinical Proteomics.13, 13. [PubMed] (*The authors contributed equally)

    • Subbannayya, T., Variar, P., Advani, J., Nair, B., Shankar, S., Gowda, H., Saussez, S., Chatterjee, A. and Prasad, T. S. K. (2016). An integrated signal transduction network of macrophage migration inhibitory factor. Journal of Cell Communication and Signaling. 10, 165-170. [PubMed]

    • Radhakrishnan, A., Nanjappa, V., Raja, R., Sathe, G. J., Chavan, S., Nirujogi, R. S., Patil, A., Solanki, H., Renuse, S., Sahasrabuddhe, N. A., Mathur, P. P., Prasad, T. S. K., Kumar, P., Califano, J. A., Sidransky, D., Pandey, A., Gowda, H. and Chatterjee, A. (2016). Dysregulation of splicing proteins in head and neck squamous cell carcinoma. Cancer Biology and Therapy. [PubMed] 

    • Subbannayya, T., Leal-Rojas, P., Barbhuiya, M., Raja, R., Renuse, S., Sathe, G., Pinto, S. M., Syed, N., Nanjappa, V., Patil, A. H., Garcia, P., Sahasrabuddhe, N. A., Nair, B., Guerrero-Preston, R., Navani, S., Tiwari, P. K., Santosh, V., Sidransky, D., Prasad, T. S. K., Gowda, H., Roa, J. C., Pandey, A. and Chatterjee, A*. (2015). Macrophage migration inhibitory factor - a therapeutic target in gallbladder cancer.BMC Cancer. 15, 843. [PubMed] (* Corresponding Author)

    • Nanjappa, V., Renuse, S., Sathe, G. J., Raja, R., Syed, N., Radhakrishnan, A., Subbannayya, T., Patil, A., Marimuthu, A., Sahasrabuddhe, N. A., Guerrero-Preston, R., Somani, B. L., Nair, B., Kundu, G. C., Prasad, T. S. K., Califano, J. A., Gowda, H., Sidransky, D., Pandey, A. and Chatterjee, A*. (2015). Chronic exposure to chewing tobacco selects for overexpression of stearoyl-CoA desaturase in normal oral keratinocytes. Cancer Biology and Therapy. 1-11. [PubMed] (* Corresponding Author)

    • Sharma, J., Balakrishnan, L., Datta, K. K., Sahasrabuddhe, N. A., Khan A. A., Sahu, A., Singhal, A., Derese, G., Raju, R., Chatterjee, A., Gowda, H., Prasad, T. S. K., Shankar, S. and Pandey, A. (2015). A knowledgebase resource for Interleukin-17 family mediated signaling. Journal of Cell Communication and Signaling. 9, 291-296. [PubMed] 

    • Mir, S. A., Rajagopalan, P., Jain, A. P., Khan, A. A., Datta, K. K., Mohan, S. V., Lateef, S. S., Sahasrabuddhe, N., Somani, B. L., Prasad, T. S. K., Chatterjee, A., Kumar, K. V. V., Kumar, M. V., Kumar, R. V., Gundimeda, S., Pandey, A. and Gowda H. (2015). LC-MS-based serum metabolomic analysis reveals dysregulation of phosphatidylcholines in esophageal squamous cell carcinoma. Journal of Proteomics. S1874-3919. [PubMed] 

    • Subbannayya, Y., Mir, S. A., Renuse, S., Manda, S. S., Pinto, S. M., Puttamallesh, V. N., Solanki, H. S., Manju, H .C., Syed, N., Sharma, R., Christopher, R., Vijayakumar, M., Veerendra Kumar, K. V., Prasad, T. S. K., Ramaswamy, G., Kumar, R. V., Chatterjee, A., Pandey, A. and Gowda, H. (2015). Identification of differentially expressed serum proteins in gastric adenocarcinoma. Journal of Proteomics. S1874-3919. [PubMed] 

    • Murthy, K. R., Rajagopalan, P., Pinto, S. M., Advani, J., Murthy, P. R., Goel, R., Subbannayya, Y., Balakrishnan, L., Dash, M., Anil, A. K., Manda, S. M., Nirujogi, R. S., Kelkar, D. S., Sathe, G. J., Dey, G., Chatterjee, A., Gowda, H., Chakravarti, S., Shankar, S., Sahasrabuddhe, N. A., Nair, B., Somani, B. L., Prasad, T. S. K. and Pandey, A. (2015). Proteomics of human aqueous humor. OMICS: A Journal of Integrative Biology. 19, 283-293. [PubMed]  

    • Subbannayya, Y., Syed, N., Barbhuiya, M. A., Raja, R., Marimuthu, A., Sahasrabuddhe, N. A., Pinto, S. M., Manda, S. S., Renuse, S., Manju, H. C., Zameer, M. A. L., Sharma, J., Brait, M., Srikumar, K., Roa, J. C., Vijaya Kumar, M., Veerendra Kumar, K. V., Prasad, T. S. K., Ramaswamy, G., Kumar, R. V., Pandey, A., Gowda, H. and Chatterjee, A.* (2015). Calcium calmodulin dependent kinase kinase 2 - a novel therapeutic target for gastric adenocarcinoma. Cancer Biology and Therapy. 16, 336-345. [PubMed] (* Corresponding Author)

    • Reddy, P. J., Sinha, S., Ray, S., Sathe, G. J., Chatterjee, A., Prasad, T. S. K., Dhali, S., Rapole, S., Panda, D. and Srivastava, S. (2015). Comprehensive analysis of temporal alterations in cellular proteome of Bacillus subtilis under curcumin treatment. PLOS ONE. 10, e0120620. [PubMed]. 

    • Zhong, J., Martinez, M., Sengupta, S., Lee, A., Wu, X., Chaerkady, R., Chatterjee, A., O´Meally, R. N., Cole, R. N., Pandey, A. and Zachara, N. E. (2015). Quantitative phosphoproteomics reveals crosstalk between phosphorylation and O-GlcNAc in the DNA damage response pathway. Proteomics.  15, 591-607. [PubMed]

    • Kim, M. S., Pinto, S. M., Getnet, D., Nirujogi, R. S., Manda, S. S., Chaerkady, R., Madugundu, A. K., Kelkar, D. S., Isserlin, R., Jain, S., Thomas, J. K., Muthusamy, B., Leal-Rojas, P., Kumar, P., Sahasrabuddhe, N. A., Balakrishnan, L., Advani, J., George, B., Renuse, S., Selvan, L. D. N., Patil, A. H., Nanjappa, V., Radhakrishnan, A., Prasad, S., Subbannayya, T., Raju, R., Kumar, M., Sreenivasamurthy, S. K., Marimuthu, A., Sathe, G. J., Chavan, S., Datta, K. K., Subbannayya, Y., Sahu, A., Yelamanchi, S. D., Jayaram, S., Rajagopalan, P., Sharma, J., Murthy, K. R., Syed, N., Goel, R., Khan, A. A., Ahmad, S., Dey, G., Mudgal, K., Chatterjee, A., Huang, T. C., Zhong, J., Wu, X., Shaw, P. G., Freed, D., Zahari, M. S., Mukherjee, K. K., Shankar, S., Mahadevan, A., Lam, H., Mitchell, C. J., Shankar, S. K., Satishchandra, P., Schroeder, J. T., Sirdeshmukh, R., Maitra, A., Leach, S. D., Drake, C. G., Halushka, M. K., Prasad, T. S. K., Hruban, R. H., Kerr, C. L., Bader, G. D., Iacobuzio-Donahue, C. A., Gowda, H. and Pandey, A. (2014). A draft map of the human proteome. Nature.  509, 575-581. [PubMed]

    • Pinto, S. M., Nirujogi, R. S., Leal-Rojas, P., Patil, A. H., Manda, S. S., Subbannayya, Y., Roa, J. C., Chatterjee, A., Prasad, T. S. K and Pandey, A. (2014). Quantitative phosphoproteomic analysis of IL-33 mediated signaling. Proteomics. 15, 532-44. [PubMed]

    • Syed, N., Barbhuiya, M. A., Pinto, S. M., Nirujogi, R. S., Renuse, S., Datta, K. K., Khan, A. A., Srikumar, K., Prasad, T. S. K., Vijaya Kumar, M., Kumar, R. V., Chatterjee, A., Pandey, A. and Gowda, H. (2014). Phosphotyrosine profiling identifies ephrin receptor A2 as a potential therapeutic target in esophageal squamous cell carcinoma. Proteomics. 15, 374-82. [PubMed]

    • Kagohara, L. T., Schussel, J. L., Subbannayya, T., Sahasrabuddhe, N., Lebron, C., Brait, M., Maldonado, L., Valle, V. B., Pirini, F., Jahuira, M., Lopez, J., Letelier, P., Brebi-Mieville, P., Ili, C., Pandey, A., Chatterjee, A., Sidransky, D. and Guerrero-Preston, R. (2014). Global and gene-specific DNA methylation pattern discriminates cholecystitis from gallbladder cancer patients in Chile. Future Oncology.11, 233-49. [PubMed]

    • Thomas, J. K., Kim, M. S., Balakrishnan, L., Nanjappa, V., Raju, R., Marimuthu, A., Radhakrishnan, A., Muthusamy, B., Khan, A. A., Sakamuri, S., Tankala, S. G., Singal, M., Nair, B., Sirdeshmukh, R., Chatterjee, A., Prasad, T. S. K., Maitra, A., Gowda, H., Hruban, R. H. and Pandey, A. (2014). Pancreatic Cancer Database: An integrative resource for pancreatic cancer. Cancer Biology and Therapy. 15, 963-7. [PubMed]

    • Marimuthu, A., Huang, T. C., Selvan, L. D. N., Renuse, S., Nirujogi, R. S., Kumar, P., Rajagopalan, S., Pandey, A., Harsha, H. C and Chatterjee, A.* (2014). Identification of targets of miR-200b by a SILAC-based quantitative proteomic approach. EuPA Open Proteomics. 4, 10-17. [PubMed] (* Corresponding Author)

    • Sahasrabuddhe, N. A., Barbhuiya, M. A., Bhunia, S., Subbannayya, T., Gowda, H., Advani, J., Shrivastav, B. R., Navani, S., Leal, P., Roa, J. C., Chaerkady, R., Gupta, S., Chatterjee, A., Pandey, A. and Tiwari, P. K. (2014). Identification of Prosaposin and Transgelin as potential biomarkers for gallbladder cancer using quantitative proteomics. Biochemical and Biophysical Research Communications.  446, 863-9. [PubMed]

    • Syed, N., Chavan, S., Sahasrabuddhe, N. A., Renuse, S., Sathe, G., Nanjappa, V., Radhakrishnan, A., Raja, R., Pinto, S. M., Srinivasan, A., Prasad, T. S. K., Srikumar, K., Gowda, H., Santosh, V., Sidransky, D., Califano, J. A., Pandey, A and Chatterjee, A.* (2014). Silencing of high-mobility group box 2 (HMGB2) modulates cisplatin and 5-fluorouracil sensitivity in head and neck squamous cell carcinoma. Proteomics. 15, 383-93. [PubMed](* Corresponding Author)

    • Selvan, L. D. N., Kaviyil, J. E., Nirujogi, R. S., Muthusamy, B., Puttamallesh, V. N., Subbannayya, T., Syed, N., Radhakrishnan, A., Kelkar, D. S., Ahmad, S., Pinto, S. M., Kumar, P., Madugundu, A. K., Nair, B., Chatterjee, A., Pandey, A., Ravikumar, R., Gowda, H. and Prasad, T. S. K. (2014). Proteogenomic analysis of pathogenic yeast Cryptococcus neoformans using high resolution mass spectrometry. Clinical Proteomics. 11, 5. [PubMed]

    • Paul, S., Banerjee, N., Chatterjee, A., Sau, T. J., Das, J.K., Mishra, P. K., Chakrabarti, P., Bandyopadhyay, A., Giri, A. K. (2014). Arsenic-induced promoter hypomethylation and over-expression of ERCC2 reduces DNA repair capacity in humans by non-disjunction of the ERCC2-Cdk7 complex. Metallomics.  6, 864-73. [PubMed].

    • Nanjappa, V., Thomas, J. K., Marimuthu, A., Muthusamy, B., Radhakrishnan, A., Sharma, R., Khan, A. A., Balakrishnan, L., Sahasrabuddhe, N., Kumar, S., Jhaveri, B. N., Sheth, K. V., Khatana, R. K., Shaw, P. G., Srikanth, S. M., Mathur, P. P., Shankar, S., Nagaraja, D., Christopher, R., Mathivanan, S., Raju, R., Sirdeshmukh, R., Chatterjee, A., Simpson, R. J., Harsha, H. C., Pandey, A. and Prasad, T. S. K. (2014). Plasma Proteome Database as a resource for proteomics research: 2014 update. Nucleic Acids Research. 42, D959-D965. [PubMed]

    • Chang, X., Izumchenko, E., Solis, L. M., Kim, M. S., Chatterjee, A., Ling, S., Monitto, C. L., Harari, P. M., Hidalgo, M., Goodman, S. N., Wistuba, I. I., Bedi, A. and Sidransky, D. (2013). The relative expression of Mig6 and EGFR Is associated with resistance to EGFR Kinase inhibitors. PLoS ONE. 8, e68966. [PubMed] 

    • Prasad, T. S. K., Verma, R., Kumar, S., Nirujogi, R. S., Sathe, G. J., Madugundu, A. K., Sharma, J., Puttamallesh, V. N., Ganjiwale, A., Myneedu, V. P., Chatterjee, A., Pandey, A., Harsha, H. C. and Narayana, J. (2013). Proteomic analysis of purified protein derivative of Mycobacterium tuberculosis. Clinical Proteomics. 10, 8. [PubMed]

    • Marimuthu, A., Chavan, S., Sathe, G. J., Sahasrabuddhe, N. A., Srikanth, S. M., Renuse, S., Ahmad, S., Radhakrishnan, A., Barbhuiya, M. A., Kumar, R. V., Harsha, H. C., Sidransky, D., Califano, J., Pandey, A. and Chatterjee, A.* (2013). Identification of head and neck squamous cell carcinoma biomarker candidates through proteomic analysis of cancer cell secretome. BBA - Proteins and Proteomics.  1834, 2308-2316. [PubMed] (* Corresponding Author)

    • Balakrishnan, L., Soman, S., Patil, Y. B., Advani, J., Thomas, J. K., Venkatesh, D. D., Urmila, K. K., Harsha, H. C., Prasad, T. S. K., Raju, R., Pandey, A., Dimitriadis, E., and Chatterjee, A.* (2013). IL-11/IL11RA receptor mediated signaling: a web accessible knowledgebase. Cell Communication and Adhesion. 20, 81-86.[PubMed] (* Corresponding Author)

    • Marimuthu, A., Subbannayya, Y., Sahasrabuddhe, N. A., Balakrishnan, L., Syed, N., Sekhar, N. R., Katte, T. V., Pinto, S. M., Srikanth, S. M., Kumar, P., Pawar, H., Kashyap, M. K., Maharudraiah, J., Ashktorab, H., Smoot, D. T., Ramaswamy, G., Kumar, R. V., Cheng, Y., Meltzer, S. J., Roa, J. C., Chaerkady, R., Prasad, T. S. K., Harsha, H. C., Chatterjee, A. and Pandey, A. (2012). SILAC-based quantitative proteomic analysis of gastric cancer secretome. Proteomics - Clinical Applications. 7, 355-66. [PubMed]

    • Radhakrishnan, A., Raju, R., Tuladhar, N., Subbannayya, T., Thomas, J. K., Goel, R., Telikicherla, D., Palapetta, S. M., Rahiman, B. A., Venkatesh, D. D., Urmila, K. K., Harsha, H. C., Mathur, P. P., Prasad, T. S. K., Pandey, A., Shemanko, C. and Chatterjee, A. (2012). A pathway map of prolactin signaling. Journal of Cell Communication and Signaling. 6, 169-173. [PubMed]

    • Ogawa,T., Liggett, T.E., Melnikov,A.A., Monitto, C.L., Kusuke, D., Shiga, K., Kobayashi, T., Horii, A., Chatterjee, A., Levenson, V. V., Koch, W., Sidransky, D. and Chang, X. Methylation of death-associated protein kinase is associated with cetuximab and erlotinib resistance. Cell Cycle. 2012, 11, 1-8 [PubMed].

    • Bhattacharjee, M., Raju, R., Radhakrishnan, A., Nanjappa, V., Muthusamy, B., Singh, K., Kuppusaami, D., Lingala, B. T., Pan, A., Mathur, P. P., Harsha, H. C., Prasad, T. S. K., Atkins, G. J., Pandey, A. and Chatterjee, A.* (2012). A bioinformatics resource for TWEAK-Fn14 signaling pathway. Journal of Signal Transduction. Article ID 376470. [PubMed]. (* Corresponding Author)

    • Chang, X., Ravi, R., Pham, V., Bedi, A., Chatterjee, A.* and Sidransky, D. Adenylate Kinase 3 sensitizes cells to cigarette smoke condensate vapor induced cisplatin resistance. 2011. PLOS One. e20806. (* Corresponding Author). [PubMed]

    • Chatterjee, A., Dasgupta, S. and Sidransky, D. Mitochondrial Subversion in Cancer. Cancer Prevention and Research (Phila). 2011. 4, 638-654. [PubMed]

    • Sen, T., Sen, N., Brait, M., Begum, S., Chatterjee, A., Hoque, M. O., Ratovitski, E. and Sidransky D. ΔNp63α confers tumor cell resistance to cisplatin through the AKT1 transcriptional regulation. Cancer Research. 2011. 71, 1167-1176. [PubMed]

    • Sen, T., Chang, X., Sidransky, D. and Chatterjee, A.* Regulation of ΔNp63α by NF-κB Cell Cycle. 2010. 9, 4841-4847. (Selected for News and Views). (* Corresponding Author). [PubMed]

    • Chatterjee, A., Chang, X., Sen, T., Ravi, R., Bedi, A. and Sidransky, D. Regulation of p53 Family Member Isoform ΔNp63α by the Nuclear Factor-κB Targeting Kinase IκB Kinase-β. Cancer Research. 2010. 70, 1419-1429. [PubMed]

    • Chatterjee, A., Sen, T., Chang, X. and Sidransky, D. Yes-associated protein 1 regulates the stability of ΔNp63α. Cell Cycle. 2010. 9, 162-167.[PubMed]

    • Chatterjee, A., Upadhyay, S., Chang, X., Nagpal, K. J., Trink, B. and Sidransky, D. U-box-type Ubiquitin E4 ligase, UFD2a Attenuates Cisplatin Mediated Degradation of ΔNp63α. Cell Cycle. 2008. 7, 1231-1237. [PubMed]

    • Chatterjee, A., Chang, X., Nagpal, K. J., Chang, S., Upadhyay, S., Califano, J.A., Trink, B. and Sidransky, D. Targeting Human 8-Oxoguanine DNA Glycosylase (hOGG1) to mitochondria protects cells from 2-methoxyestradiol-induced mitochondria dependent apoptosis. Oncogene. 2008. 27, 3710-3720. [PubMed]

    • Zhou, S., Kachhap, S., Sun, W., Wu, G., Chuang, A., Poeta, L., Grumbine, L., Mithani, K. S., Chatterjee, A., Koch, W., Westra, H. W., Maitra, A., Glazer, C., Carducci, M., Sidransky, D., McFate, T., Verma, A. and Califano, J.A. Frequency and phenotypic implications of mitochondrial DNA mutations in human squamous cell cancers of the head and neck. Proceedings of National Academy of Science, U S A. 2007. 104, 7540-7545. [PubMed]

    • Upadhyay,S.*, Chatterjee, A.*, Trink, B., Sommer, M., Ratovitski , E. and Sidransky, D. TAp63γ regulates OGG1 and repair of oxidative damage in cancer Cell Lines. Biochemical and Biophysical Research Communications. 2007. 356, 823-828. (* Equal contribution). [PubMed]

    • Wu,G., Guo, Z., Chatterjee, A., Huang, X., Rubin, E., Wu, F., Mambo, E., Chang, X., Osada, M., Sook Kim, M., Moon, C., Califano, A.J., Ratovitski, E., Gollin, S.M., Sukumar, S., Sidransky, D. and Trink,B. Overexpression of Glycosylphosphatidylinositol (GPI) Transamidase Subunits Phosphatidylinositol Glycan Class T and/or GPI Anchor Attachment 1 Induces Tumorigenesis and Contributes to Invasion in Human Breast. Cancer Research. 2006. 66, 9829-9836. [PubMed]

    • Chatterjee, A., Mambo, E., Zhang, Y., DeWeese, T. and Sidransky, D. Targeting of mutant hogg1 in mammalian mitochondria and nucleus: effect on cellular survival upon oxidative stress. BMC Cancer. 2006. 6, 235. [PubMed]

    • Upadhyay, S., Liu, C., Chatterjee, A., Hoque, M.O., Sook Kim, M., Engles, J., Westra, W., Trink, B., Ratovitski, E. and Sidransky, D. LKB1/STK11 suppresses COX-2 induction and cellular invasion through PEA3 in lung cancer. Cancer Research. 2006. 66, 7870-7879.[PubMed]

    • Hoque, M.O., Begum, S., Topaloglu, O., Chatterjee, A., Rosenbaum, E., Criekinge, W.V., Westra, W., Schoenberg, M., Zahurak, M., Goodman, S.N. and Sidransky, D. Quantitation of promoter methylation of multiple genes in unine DNA and bladder cancer detection. Journal of the National Cancer Institute. 2006. 98, 996 – 1004. [PubMed]

    • Chatterjee, A., Mambo, E. and Sidransky, D. Mitochondrial DNA mutations in human cancer. Oncogene. 2006. 25, 4663-4674. [PubMed]

    • Zhang, H., Chatterjee, A. and Singh, K. K. Saccharomyces cerevisiae polymerase {zeta} functions in mitochondria. Genetics. 2006. 172, 2683-2688. [PubMed]

    • Chatterjee, A., Mambo, E., Osada, M., Upadhyay, S. and Sidransky, D. The Effect of p53 RNAi and p53 knockout on human 8-oxoguanine DNA glycosylase (hOgg1) activity. FASEB J. 2006. 20, 112-114. [PubMed]

    • Kim, M.M., Glazer, C., Mambo, E., Chatterjee, A., Zhao, M., Sidransky,D. and Califano, J.A. Head and neck cancer cell lines exhibit differential mitochondrial repair deficiency in response to 4NQO. Oral Oncology. 2006. 42, 201-207. [PubMed]

    • Mambo, E.*, Chatterjee, A.*, Xing, M., Tallini, G., Haugen, B.R., Yeung, S., Sukumar, S. and Sidransky, D. Tumor-specific Changes in mtDNA Content in Human Cancer. International Journal of Cancer. 2005. 116, 920-924. (* Equal contribution) .[PubMed]

    • Mambo, E.*, Chatterjee, A.*, Souza-Pinto, N., Mayard, S., Hogue, B.A., Hoque, M.O., Dizdaroglu, M., Bohr, V.A. and Sidransky,D. Oxidized Guanine Lesions and hOgg1 Activity in Lung Cancer. Oncogene. 2005. 24, 4496-508. (* Equal contribution) . [PubMed]

    • Wu, G., Xing, M., Mambo, E., Huang, X., Liu, J., Guo, Z., Chatterjee, A., Goldenberg, D., Gollin, S.M., Sukumar, S., Trink,B. and Sidransky, D. Somatic mutation and gain of copy number of PIK3CA in human breast cancer. Breast Cancer Research. 2005. 7, R609-616. [PubMed]

    • Rasmussen, A. K., Chatterjee, A., Rasmussen, L. J. and Singh, K. K. Mitochondria as determinant of genetic stability in Saccharomyces cerevisiae. Nucleic Acids Research. 2003. 31, 3909-3917. [PubMed]

    • Chatterjee, A. and Singh, K. K. Uracil-DNA glycosylase-deficient yeast exhibit a mitochondrial mutator phenotype. Nucleic Acids Research. 2001. 29, 4935-4940. [PubMed]

    • Chatterjee, A., Kanjilal, S. and Bhattacharyya, A. K. Purification of human seminal acrosin inhibitor and its kinetics. Journal of Biosciences. 1999. 24, 323-328. [PubMed]

     

    Copyright © 2016 yenepoya.edu.in All Rights Reserved.