Center for Systems Biology and Molecular Medicine

Center for Systems Biology and Molecular Medicine

CSBMM
Bhagya Nekrakalaya, Ph.D.

Assistant Professor


Biography

Dr. Bhagya N. obtained her Ph.D. in 2013 from Mangalore University for the work on indirect somatic embryogenesis mediated plantlet regeneration and, production of bioactive metabolites from in vitro grown cultures. Further, she was awarded with Post Doctoral fellowship for Women from University Grants Commission, New Delhi to work on anticancer potential of alkaloids and associated molecular mechanisms at Mangalore University. Recently, Dr. Bhagya joined Centre for Systems Biology and Molecular Medicine (CSBMM) of Yenepoya Research Centre, Yenepoya (Deemed to be University) and, working on plant proteomics and metabolites. She is a reviewer for the Journal of Proteins and Proteomics.

Scientific discipline
  • Plant proteomics
  • Anticancer mechanism of plant alkaloids
    • Education
  • Ph.D. in Plant Biotechnology, Mangalore University, 2013
  • M.Sc. Biotechnology, Mangalore University, 2005
    • Positions held
    • Lecturer – St. Aloysius College, Mangalore, 2005 -2008
    Honors and Awards
    • Post Doctoral Fellowship for Women, 2012-13
    • DS Kothari Post Doctoral Fellowship, UGC, India, 2013-14 (not availed)
    • DST Start Up scheme award, 2014 (not availed)
    • Karnataka State Eligibility Test for Lectureship (KSET), 2013)
    • Senior Research Fellowship, VGST, Department of IT, BT and S & T, Govt. of Karnataka, India, 2012 - 2013
    • Junior Research Fellowship, UGC-RFSMS, New Delhi, India 2008 - 2012
    Publications

    Research papers: 19 ; Review articles: 2 ; Book Chapters: 3

    • Bhagya, N. and Chandrashekar, K. R. (2019). Tetrandrine isolated from Cyclea peltata induces cytotoxicity and apoptosis through ROS and caspase pathways in breast and pancreatic cancer cells. In Vitro Cellular & Developmental Biology-Animal.
    • Bhagya, N. and Chandrashekar, K. R. (2018). Tetrandrine and cancer – An overview on the molecular approach. Biomedicine & Pharmacotherapy. 97, 624–632.
    • Bhagya, N. and Chandrashekar, K. R. (2018). In vitro pharmacological potential of Epiprinus mallotiformis – An endemic species of Western Ghats. IJNPR. 9(2), 108-116.
    • Kalluraya, B., Jois, H. S., Asma, Aparna, K., Bhagya, N. and Chandrashekar, K. R. (2017). Microwave-assisted synthesis and biological studies of thiazoles, thiazolones containing quinoline, and tetrazole moiety. Indian Journal of Heterocyclic Chemistry. 27, 443-449.
    • Chandrashekar, K. R. and Bhagya, N. (2017). Medicinal Plants: An Introduction about the Medicinal Plants of M.V. Shasthry Herbal Garden. Vol. 1. Mangalore University, Mangalore, Karnataka
    • Manasa, D. J., Chandrashekar, K. R. and Bhagya, N. (2017). Rapid invitro callogenesis and phytochemical screening of leaf, stem and callus of Musseanda frondosa Linn.- a medicinal plant. Asian J. Pharm. Clin Res. 10, 81-86
    • Bhagya, N. and Chandrashekar, K. R. (2016). Tetrandrine – A molecule of wide bioactivity. Phytochemistry. 125, 5-13.
    • Bhagya, N. and Chandrashekar, K. R. (2016). Cyclea peltata: secondary metabolites and pharmacological potential. Book chapter in book “Ethnomedicinal Plants: Phytochemistry and Pharmacological Profiles” Vol-1, Ed: H P Sharma, Agrobios (International), Jodhpur, India. 167-182.
    • Vidyashree J. H. S., Kalluraya, B., Babu, M., Bhagya, N. and Chandrashekar, K. R. (2015). Microwave assisted synthesis and biological activity of 4-(2-(aryl substituted) hydrazono)-1-(2-(p-tolyloxyacetyl)-3-methyl-1h-pyrazol-5-one. Indian Journal of Heterocyclic Chemistry. 25, 07-10.
    • Bhagya, N. and Chandrashekar, K. R. (2013). Effect of growth regulators on callus induction from Cyclea peltata (Lam.) Hook. F. Thoms. Asian J. Pharm. Clin. Res. 6, 85-88.
    • Bhagya, N., Chandrashekar, K. R., Karun, A. and Bhavyashree, U. (2013). Plantlet regeneration through indirect shoot organogenesis and somatic embryogenesis in Justicia gendarussa Burm. f. a medicinal plant. J Plant Biochem Biotechnol. 22, 474-482.
    • Bhagya, N. and Chandrashekar, K. R. (2013). Effect of auxins with cytokinins on stem and leaf explants of Justicia gendarussa Burm. f. IJLST. 6, 1-8.
    • Bhagya, N. and Chandrashekar, K. R. (2013). In vitro production of bioactive compounds from stem and leaf explants of Justicia gendarussa Burm. f. Asian J. Pharm. Clin. Res. 6, 100-105.
    • Bhagya, N. and Chandrashekar, K. R. (2013). Evaluation of plant and callus extracts of Justicia gendarussa Burm. f. for phytochemicals and antioxidant activity. Int. j. Pharm. Sci. 5, 82-85.
    • Bhagya, N., Chandrashekar, K. R., Muralidharan, K. and Amarnath, C. H. (2012). Phytochemical analysis and antioxidant activity of in vitro cultured stem callus of Cyclea peltata (Lam.). Hook. f. & Thoms. J. Trop. Med. Plants. 13, 117-123.
    • Bhagya, N. and Chandrashekar, K. R. (2011). Further research on callus induction and organogenesis in Cyclea peltata. J. Trop. Med. Plants. 12, 53-58.
    • Bhagya, N., Sheik, S., Sharma, S. M. and Chandrashekar, K. R. (2011). Isolation of endophytic Colletotrichum gloeosporioides Penz. from Salacia chinensis and its antifungal sensitivity. Journal of Phytology. 3, 20-22.
    • Bhagya, N. and Chandrashekar, K. R. (2010). Effect of auxin concentration on callus induction from Justicia gendarussa L. stem and leaf explants. IJBST. 3, 27-35.
    • Asha, A., Bhagya, N., Prathibha, A., Ramya, S., Reshma, M. and Joji, M. G. (2009). Anti diabetic effect of insulin plant – Costus igneus on streptozotocin induced diabetic rats. Explorations - A multi disciplinary refereed research journal. 2, 85-103.

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