CSBMM
Prashant Kumar Modi, Ph.D.

Senior Scientific Officer


Biography

Dr. Prashant Kumar Modi obtained his Ph.D. from Banaras Hindu University. During this period he studied the effects of aging on glial cells with special emphasis on the astrocytes of the mice brain. During his post-doctoral training at Dr. Pushkar Sharma's laboratory, National Institute of Immunology, New Delhi, he worked on delineating the molecular mechanisms involved in cell cycle related neuronal apoptosis in Alzheimer’s disease. He has been a recipient of DBT Research Associateship during 2011-2015 from Department of Biotechnology, Govt. of India. Currently, he is involved in the identification of biomarkers and novel therapeutic targets in neurodegenerative diseases such as Parkinson’s disease and Alzheimer’s disease using cutting-edge technologies in genomics, proteomics and metabolomics.

Scientific discipline
  • Genomics, proteomics and bioinformatics
  • Neurodegenerative diseases
  • Education
  • Ph.D. in Biochemistry, Banaras Hindu University, India, 2009
  • M.Sc. in Biochemistry, Devi Ahilya University, India, 2002
  • Positions held
    • Faculty Scientist, YU-IOB Center for Systems Biology and Molecular Medicine, Mangalore, India
    • DBT Research Associate, National Institute of Immunology New Delhi, India, 2011-2015
    • Project Associate, National Institute of Immunology New Delhi, India, 2010-2011
    Honors and Awards
    • Awarded SNCI-AIIMS 2013 award for the best oral presentation in 27th Annual Meeting of Society for Neurochemistry, India (SNCI) &International Conference on recent advances in molecular mechanisms in neurological disorders, AIIMS New Delhi
    • DBT Research Associateship( 2011-2012), Dept. of Biotechnology, India, 2011-2012
    • Senior Research Fellowship(2007-2009), Indian Council of Medical Research, India, 2007-2009
    • Qualified CSIR-UGC NET(LS) December, 2002
    Publications

    Research papers:18; Review articles: 0; Book Chapters: 0

    • Najar. M. A., Modi. P. K., Ramesh. P., Sidransky. D., Gowda. H., Prasad T.S.K., and Chatterjee. (2021). "Molecular profiling associated with Calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) mediated carcinogenesis in gastric cancer". Journal of Proteome Research. In press.
    • Shaikh, S., Najar, M. A., Prabhu, A., Rex, D. A. B., Chanderasekaran, J., Behera, S., Modi, P., Prasad, T. S. K. and Bhandary, Y. (2021). The unique molecular targets associated anti-oxidant and anti-fibrotic activity of curcumin in in vitro model of acute lung injury: A proteomic approach. BioFactors. In press.
    • Karthikkeyan, G., Pervaje, R., Pervaje, S. K., Prasad, T.S.K., and Modi, P.K. (2021). Prevention of MEK-ERK-1/2 hyper-activation underlines the neuroprotective effect of Glycyrrhiza glabra L. (Yashtimadhu) against rotenone-induced cellular and molecular aberrations. Journal of Ethnopharmacology. In Press
    • DasGupta, M., Kumaresan, A., Saraf, K. K., Karthikkeyan, G., Prasad, T. S. K., Modi, P. K., Ramesha, K., Jeyakumar, S. and Manimaran, A. (2021). Preliminary comparative deep-metabolomic analysis of spermatozoa from zebu and crossbred cattle suggests associations between metabolites, sperm quality and fertility. Reproduction, Fertility and Development. In Press.
    • Karthikkeyan, G., Pervaje, R., Subbannayya, Y., Patil, A. H., Modi, P. K*. and Prasad, T. S. K. (2020). Plant Omics: Metabolomics andNetwork Pharmacology of Liquorice, Indian Ayurvedic medicine Yashtimadhu. OMICS: A Journal of Integrative Biology. In Press. (* Corresponding author)
    • Karthikkeyan, G., Najar, M. A., Pervaje, R., Pervaje, S. K., Modi, P. K*. and Prasad, T. S. K. (2020). Identification of Molecular Network Associated with Neuro protective Effects of Yashtimadhu (Glycyrrhiza glabra L.) by Quantitative Proteomics of Rotenone-Induced Parkinson’s Disease Model. ACS Omega. [PubMed] (* Corresponding author)
    • Dagamajalu, S., Rex, D. A. B., Gopalakrishnan, L., Karthikkeyan, G., Gurtoo. S., Modi, P. K., Mohanty, V., Rahiman, M., Soman, S., Raju, R., Tiwari, V. and Prasad, T. S. K. (2020). A network map of endothelin mediated signaling pathway. Journal of Cell Communication and Signaling. In press.
    • Gouda, M., Rex D. A. B., Sindu, P. E. S., Modi, P. K., Chanderasekaran, J., Bhandary, Y. P. (2020). Proteomics analysis revealed the importance of inflammation-mediated downstream pathways and the protective role of curcumin during bleomycin-induced pulmonary fibrosis in C57BL/6 mice. Journal of Proteome Research. [PubMed]
    • Chauhan, M., Modi, P. K. and Sharma, P. (2020). Aberrant activation of neuronal cell cycle caused by dysregulation of ubiquitin ligase Itch results in neurodegeneration.Cell Death Disease. [PubMed]
    • Sandeep, K., Varshasnata, M., Tyagi, A., Behera, S. K., Patil, A. H., Sneha M Pinto, S. M., Prasad, T. S. K., Modi, P. K*., and Gowda, H*. (2020). CusVarDB: A tool for building customized sample-specific variant protein database from next-generation sequencing datasets. F1000Research. (* corresponding author)
    • Keekan, K. K., Hallur, S., Modi, P. K., Shastry, R. P. (2020). Antioxidant Activity and Role of Culture Condition in the Optimization of Red Pigment Production by Talaromyces purpureogenus KKP Through Response Surface Methodology. Current Microbiology. [PubMed]
    • Saraf, K. K., Kumaresan, A. , Dasgupta, M., Karthikkeyan, G., Prasad, T. S. K., Modi, P. K., Ramesha, K., Jeyakumar, S., Manimaran, A. (2020). Metabolomic fingerprinting of bull spermatozoa for identification of fertility signature metabolites. Molecular Reproduction and Development. [PubMed]
    • Deolankar, S.C*., Modi, P. K*., Subbannayya, Y., Pervaje, R., Prasad, T. S. K. (2020). Molecular Targets from Traditional Medicines for Neuroprotection in Human Neuro degenerative Diseases. OMICS: A Journal of Integrative Biology. [PubMed] (* Equal first author)
    • Modi, P. K*., Prabhu, A*., Bhandary, Y. P*., Shenoy, P. S.*, Hegde, A., Es, S. P., Johnson, R. P., Das, S. P., Vazirally, S., Rekha, P. D. (2019). Effect of calcium glucoheptonate on proliferation and osteogenesis of osteoblast-like cells in vitro. PLos One. 14, e0222240. [PubMed] (* Equal first author)
    • Deolankar, S. C., Patil, A. H., Koyangana, S. G., Subbannayya, Y., Prasad, T. S. K. and Modi, P. K*. (2019). Dissecting Alzheimer’s disease molecular substrates by proteomics and discovery of novel post-translational modifications (PTMs). OMICS: A Journal of Integrative Biology. [PubMed] (* corresponding author)
    • Sahu, A., Gopalakrishnan, L., Gaur, N., Chatterjee, O., Mol, P., Modi, P. K., Dagamajalu, S., Advani, J., Jain, S. and Prasad, T. S. K. (2018). The 5-Hydroxytryptamine signaling map: an overview of the serotonin-serotonin receptor-mediated signaling network. Journal of Cell Communication and Signaling. 12, 731-735. [PubMed]
    • Modi, P. K., Jaiswal, S. and Sharma P. (2016). Regulation of Neuronal Cell Cycle and Apoptosis by MicroRNA 34a. Molecular and Cellular Biology. 36:84-94. [PubMed]
    • Modi, P. K.*, Komaravelli, N.*, Singh, N. and Sharma P. (2012). Interplay between MEK-ERK signaling, cyclin D1 and cyclin dependent kinase 5 regulates cell cycle reentry and apoptosis of neurons. Molecular Biology of the Cell. 18:3722-30. (Recommended by the faculty of 1000), (*Equal contribution). [PubMed]
    • Modi, P. K. and Kanungo, M. S. (2010). Age-dependent expression of S100beta in the brain of mice. Cellular and Molecular Neurobiology. 5:709-16. [PubMed]