Center for Systems Biology and Molecular Medicine

Center for Systems Biology and Molecular Medicine

CSBMM
Shobha Dagamajalu, Ph.D.

Associate professorr


Biography

Dr. Shobha D. is currently involved in molecularization of traditional medicines/ ayurvedic drugs which are having anticancer activity by using proteomics and metabolomics approaches which can be used for the subsequent development of cancer treatment. She is also working on the drug repurposing of existing licensed non-oncology drugs for the cancer therapy. Dr. Shobha is involved in development the signaling pathways for important molecules related to cardiovascular diseases, cancer, and inflammation related diseases to provide a platform to the scientific community to identify novel therapeutic drug targets.

Scientific discipline
  • Proteomics and Genomics
  • Infectious Diseases
    • Education
  • Ph.D in Plant Molecular Biology, Mangalore University, Mangala Gangothri, Mangalore
  • M.Sc in Biotechnology, St. Aloysius College, Mangalore
    • Positions held
    • Post Doctoral Fellow, Center for Systems Biology and Molecular Medicine, Mangalore, India, 2017
    • Post Doctoral Fellowship, Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia, 2014-2016
    • Senior Research Fellow, CPCRI (ICAR), Regional Station, Vittal, 2011-2014
    • Junior Research Fellow, DCR (ICAR), Puttur, 2006-2011
    • Project Assistant, DCR (ICAR), Puttur, 2005-2006
    Honors and Awards
    • DBT Junior Research Fellowship, Department of Biotechnology, Government of India, 2007-2010
    • Recipient of Senior Research Fellow, CSIR, Government of India
    • Recipient of Junior Research Fellow, ICMR, Government of India
    Publications

    Research papers: 24 ; Review articles: 1 ; Book Chapters: 1

    • Shaikh, S. B., Balaya, R. D. A., Dagamajalu, S., Bhandary, Y. P., Unwalla, H., Prasad, T. S. K., & Rahman, I. (2024). A signaling pathway map of plasminogen activator inhibitor-1 (PAI-1/SERPINE-1): a review of an innovative frontier in molecular aging and cellular senescence. Cell Communication and Signaling, 22(1), 544.

    • Suchitha, G. P., Dagamajalu, S., Keshava Prasad, T. S., & Devasahayam Arokia Balaya, R. (2024). A Comprehensive Network Map of Interleukin-26 Signaling Pathway. Journal of Interferon & Cytokine Research, 44(9), 408–413.

    • Shaji, V., Dagamajalu, S., Sanjeev, D., George, M., Kanekar, S., Prasad, G., Keshava Prasad, T. S., Raju, R., & Devasahayam Arokia Balaya, R. (2024). Deciphering the Receptor-Mediated Signaling Pathways of Interleukin-19 and Interleukin-20. Journal of Interferon & Cytokine Research, 44(9), 388–398.

    • Suchitha, G. P., Devasahayam Arokia Balaya, R., Keshava Prasad, T. S., & Dagamajalu, S. (2024). A signaling network map of Lipoxin (LXA4): an anti-inflammatory molecule. Inflammation Research, 73(7), 1099–1106.

    • Giridhara Prema, S., Chandrasekaran, J., Kanekar, S., George, M., Keshava Prasad, T. S., Raju, R., Dagamajalu, S., & Balaya, R. D. A. (2024). Cisplatin and Procaterol Combination in Gastric Cancer? Targeting Checkpoint Kinase 1 for Cancer Drug Discovery and Repurposing by an Integrated Computational and Experimental Approach. Omics: A Journal of Integrative Biology, 28(

    • Rex, D. A. B., Dagamajalu, S., Gouda, M., Suchitha G. P., Chanderasekaran, J., Raju, R., Prasad, T. S. K., and Bhandary, Y. P (2022). A comprehensive network map of IL-17A signaling pathway. Journal of Cell Communication and Signaling. In press.

    • Rex, D. A. B., Vaid, N., K. Deepak, K., Dagamajalu, S., Prasad, T. S. K. (2022). A comprehensive review on current understanding of Bradykinin in COVID-19 and inflammatory diseases. Molecular Biology Reports. In press.

    • Rex, D. A. B., Suchitha G. P., Palollathil, A., Kanichery, A., Prasad, T. S. K. and Dagamajalu, S. (2022). The network map of Urotensin-II mediated signaling pathway in physiological and pathological conditions. Journal of Cell Communication and Signaling. In Press.

    • Rex, D. A. B., K. Deepak, K., Vaid, N., Dagamajalu, S., Kandasamy, R. K., Flo, T. H. and Prasad, T. S. K. (2021). A modular map of Bradykinin-mediated inflammatory signaling network. Journal of Cell Communication and Signaling. In press.

    • Najar, M. A., Aravind, A., Dagamajalu, S., Sidransky, D., Ashktorab, H., Smoot, D. T., Gowda, H., Prasad, T. S. K., Modi, P. K. and Chatterjee, A. (2021). Hyperactivation of MEK/ERK pathway by Ca 2+ /calmodulin-dependent protein kinase kinase 2 promotes cellular proliferation by activating cyclin-dependent kinases and minichromosome maintenance protein in gastric cancer cells. Molecular Carcinogenesis. [PubMed]

    • Rex, D. A. B., Dagamajalu, S., Raju, R., Kandasamy, R. K. and Prasad T. S. K. (2021). SARS-CoV-2 signaling pathway map: A functional landscape of molecular mechanism in COVID-19. Journal of Cell Communication and Signaling. In press.

    • Dagamajalu, S., Rex, D. A. B., Philem, P. D., Rainey, J. K., and Prasad, T. S. K. (2021). A network map of apelin-mediated signaling. Journal of cell communication and signaling. In Press
    • Dagamajalu, S#., Rex, D. A. B#., Palollathil, A., Shetty, R., Bhat, G., Cheung, L.W.T and Prasad, T. S. K. (2020). A pathway map of AXL receptor-mediated signaling network. Journal of Cell Communication and Signaling. In press.(# These authors contributed equally to the manuscript)
    • Dagamajalu, S#., Rex, D. A. B#., Gopalakrishnan, L., Karthikkeyan, G., Gurtoo. S., Modi, P. K., Mohanty, V., Rahiman, M., Soman, S., Raju, R., Tiwari, V. and Prasad, T. S. K. (2020). A network map of endothelin mediated signaling pathway. Journal of Cell Communication and Signaling. In press. (# These authors contributed equally to the manuscript)
    • Sahu, A., Gopalakrishnan, L., Gaur, N., Chatterjee, O., Mol, P., Modi, P. K., Dagamajalu, S., Advani, J., Jain, S. and Prasad, T. S. K. (2018). The 5-Hydroxytryptamine signaling map: an overview of the serotonin-serotonin receptor-mediated signaling network. Journal of Cell Communication and Signaling. [PubMed].
    • Sahu, A., Gopalakrishnan, L., Gaur, N., Chatterjee, O., Mol, P., Modi, P. K., Dagamajalu, S., Advani, J., Jain, S. and Prasad, T. S. K. (2018). The 5-Hydroxytryptamine signaling map: an overview of the serotonin-serotonin receptor-mediated signaling network. Journal of Cell Communication and Signaling. In press.
    • Thimmappaiah, Dagamajalu, S., Mohana G.S, Adiga, J.D. & Bhat, P.G. (2016).Fingerprinting of released varieties of cashew based on DNA markers. Vegetos. [PubMed]
    • Dieye, Y., Mbengue, B., Dagamajalu, S., Fall, M. M., Loke, M. F., Nguer, C. M., Thiam A., Vadivelu, J. & Dieye, A. (2016). Cytokine response during non-cerebral and cerebral malaria: evidence of a failure to control inflammation as a cause of death in African adults. Peer J. [PubMed]
    • Dagamajalu, S., Thimmappaiah & Jose, C.T. (2013). Molecular characterization and association analysis in cashew using RAPD and ISSR markers. Journal of Plantation Crops. [PubMed]
    • Dagamajalu, S. & Thimmappaiah. (2011). Identification of RAPD markers linked to nut weight and plant stature in cashew. Scientia Horticulturae. 129, 637-641. [PubMed]
    • Thimmappaiah, Dagamajalu, S., Sequiera, M.G. & Goveas, S.W. (2010). Cashew (Chapter 15). In: Advances in Hortuculture Biotechnology— Molecular Markers and Marker Assisted Selection— Fruit Crops, Plantation Crops and Spices (Volume III), pp 330, Westville Publishing House, New Delhi.
    • Thimmappaiah, Goveas, S.W., Dagamajalu, S. & Sequiera, M.G. (2009). Assessment of genetic diversity in cashew germplasm using RAPD and ISSR markers. Scientia Horticulturae. 120, 411-417. [PubMed]
    • Thimmappaiah., Sequiera, M.G., Dagamajalu, S. & Anil, S.R. (2009). Assessment of cashew species for molecular diversity. Journal of Plantation Crops.37, 146-151. [PubMed]
    • Nagaraja, K.V., Dagamajalu, S. & Yogeesha, A. (2007). Extraction of tannin from cashew kernel testa at acidic P H . Journal of Food Science & Technology
    • Nagaraja, K.V, Dagamajalu, S. & Yogeesha, A. (2007). Preparation and Biochemical analysis of cashew apple powder. Journal of Food Science & Technology. 45, 228-236. [PubMed]
    • Ananda, K.S., Rajesh, B. & Dagamajalu, S. (2005). Yield performances of exotic accessions of arecanut. Indian Journal of Plant genetic Resources. 18, 114-116.[PubMed]

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