Center for Systems Biology and Molecular Medicine

An ICMR collaborating centre of excellence (ICMR-CCoE)

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Publications



1.  

Vijayakumar P, Mishra A, Pinto SM, Subbannayya Y, Sood R, Prasad TSK. Proteomics analysis of duck lung tissues in response to highly pathogenic avian influenza virus. Microorganisms. 2024; 

DOI


2.  

Vasishta S, Ammankallu S, Umakanth S, Prasad TSK, Joshi MB. DNA methyltransferase isoforms regulate endothelial cell exosome proteome composition. 2024.

DOI


3.  

Vasishta S, Ammankallu S, Poojary G, Gomes SM, Ganesh K, Umakanth S, et al. High glucose induces DNA methyltransferase 1 dependent epigenetic reprogramming of the endothelial exosome proteome in type 2 diabetes. International Journal of Biochemistry & Cell Biology. 2024; 

DOI


4.  

Usha T, Hemavathi KN, Goyal AK, Abhinand CS, Dhivya S, Cholarajan A, Joshi N, Babu D, Middha SK. Investigating emodin derivatives against SARS-CoV-2 found in medicinal herbs. Kuwait Journal of Science. 2024;

DOI


5.  

Thomas SD, Vijayakumar K, John L, Krishnan D, Rehman N, Revikumar A. Machine learning strategies in microRNA research. 2024;

DOI


6.  

Suchitha GP, Devasahayam Arokia Balaya R, Prasad TK, Dagamajalu S. A signaling network map of Lipoxin (LXA4): an anti-inflammatory molecule. Inflammation Research. 2024;

DOI


7.  

Suchitha GP, Jaikanth C, Saptami K, George M, Prasad TSK, Raju R. Cisplatin and Procaterol combination in gastric cancer? Targeting checkpoint kinase 1 (CHK1) for cancer drug discovery and repurposing by an integrated computational and experimental approaches. OMICS. 2024;

DOI


8.  

Suchitha GP, Dagamajalu S, Prasad TSK, Rex DAB. A comprehensive network map of Interleukin-26 signaling pathway. J Interferon Cytokine Res. 2024; 

DOI


9.  

Singh I, Hoti SL, Chauhan N, Joshi RK, Prasad TSK, Sarikhani M. Immunomodulation of streptozotocin-induced Type 1 Diabetes Mellitus in mouse model by Macrophage Migration Inhibitory Factor-2 (MIF-2) homologue of human lymphatic filarial parasite, Wuchereria bancrofti. 2024.

DOI


10.  

Singh I, Anagha A, Kotimoole CN, Modi PK, Prasad TSK, Hoti SL. Unpacking immune modulation as a site of therapeutics innovation for nematode parasite Wuchereria bancrofti. 2024.

DOI


11.  

Shaji V, Dagamajalu S, Sanjeev D, George M, Kanekar S, Prasad G. Deciphering the receptor-mediated signaling pathways of Interleukin-19 and Interleukin-20. J Interferon Cytokine Res. 2024; 

DOI


12.  

Shaikh SB, Rex DAB, Dagamajalu S, Bhandary YP, Unwalla H, Prasad TSK, et al. A signaling pathway map of plasminogen activator inhibitor 1 (PAI 1/SERPINE 1): a review of an innovative frontier in molecular aging and cellular senescence. Cell Communication and Signaling. 2024;

DOI


13.  

Devasahayam Arokia Balaya R, Palollathil A, Kumar ST, Chandrasekaran J, Upadhyay SS, Parate SS, Sajida M, Karthikkeyan G, Prasad TS. Role of Hemigraphis alternata in wound healing: metabolomic profiling and molecular insights into mechanisms. Scientific Reports. 2024;  

DOI


14.  

Ramesh P, Nisar M, Ammankallu S, Babu S, Nandakumar R, Abhinand CS, Prasad TS, Codi JA, Raju R. Delineating protein biomarkers for gastric cancers: A catalogue of mass spectrometry-based markers and assessment of their suitability for targeted proteomics applications. Journal of Proteomics. 2024

DOI


15.  

Priyanka P, Gopalakrishnan AP, Nisar M, Shivamurthy PB, George M, John L. A global phosphosite-correlated network map of Thousand And One Kinase 1 (TAOK1. Int J Biochem Cell Biol. 2024;

DOI


16.  

Pooja YT, Nair AS, D’silva S, Aravind A, Mallya S, Soman SP. Neutrophils display distinct post-translational modifications in response to varied pathological stimuli. Int Immunopharmacol. 2024; 

DOI


17.  

Parate SS, Upadhyay SS, Amrutha S, Karthikkeyan G, Pervaje R, Abhinand CS. Comparative metabolomics and network pharmacology analysis reveals shared neuroprotective mechanisms of Bacopa monnieri (L.) Wettst and Centella asiatica (L.) Urb. Mol Neurobiol. 2024;

DOI


18.  

Palollathil A, Babu S, Abhinand CS, Mathew RT, Vijayakumar M, Prasad TS. Proteomic profiling of oral squamous cell carcinoma tissues altered-related proteins: implications for personalized therapy. Expert review of proteomics. DOI


19.  

Pai AA, Upadhyay SS, Thattai AKS, Parate SS, Illangeswaran RST, Renji RM. Global plasma metabolomic profiling reveals dysregulated lipid metabolism in patients with hepatic sinusoidal obstruction syndrome - a pilot biomarker study. Transplant Cell Ther. 2024; 

DOI


20.  

Munjal A, Rex DA, Prasad TK, Mukherjee S, Pati S, Singh S. Mass spectrometric identification of the secretome of Plasmodium falciparum merozoites to provide novel candidates for vaccine development pipeline. Authorea Preprints. 2024;

DOI


21.  

Munjal A, Rex DAB, Garg B, Prasad TSK, Mishra SK, Malhotra Y. Mass spectrometric and Artificial Intelligence-based identification of the secretome of Plasmodium falciparum merozoites to provide novel candidates for vaccine development pipeline. Proteomics Clin Appl. 2024;

DOI


22.  

Mishra D, Shekhar S, Subba P, Prasad TSK, Chakraborty S, Chakraborty N. Wheat TaNACα18 functions as a positive regulator of high-temperature adaptive responses and improves cell defense machinery. Plant J. 2024; 

DOI


23.  

Mahin A, Soman SP, Modi PK, Raju R, Keshava Prasad TS, Abhinand CS. Meta-analysis of the serum/plasma proteome identifies significant associations between COVID-19 with Alzheimer’s/Parkinson’s diseases. Journal of neurovirology. 2024;

In press


24.  

Mahin A, Chikmagalur Ravindra S, Ramesh P, Naik P, Raju R, Keshava Prasad TS, Abhinand CS. Unveiling Actin Cytoskeleton Role in Mediating Chikungunya-Associated Arthritis: An Integrative Proteome–Metabolome Study. Vector-Borne and Zoonotic Diseases. 2024;

DOI


25.  

Kunnath AN, Parker SK, Crasta DN, Kunhiraman JP, Madhvacharya VV, Kumari S, Nayak G, Lakshmi RV, Modi PK, Prasad TS, Kumar A. Metformin augments major cytoplasmic organization except for spindle organization in oocytes cultured under hyperglycemic and hyperlipidemic conditions: An in vitro study. Toxicology and Applied Pharmacology. 2024

DOI


26.  

Kotimoole CN, Ramya VK, Kaur P, Reiling N, Shandil RK, Narayanan S. Discovery of species-specific proteotypic peptides to establish a spectral library platform for the identification of non-tuberculosis mycobacteria from mass spectrometry-based proteomics. J Proteome Res. 2024; 

DOI


27.  

Hemavathi KN, Skariyachan S, Raju R, Prasad TSK, Abhinand CS. Computational screening of potential anti-inflammatory leads from Jeevaneeya Rasayana plants targeting COX-2 and 5-LOX by molecular docking and dynamic simulation approaches. Comput Biol Med. 2024; 

DOI


28.  

Hemavathi KN, Middha SK, Raju R, Pilankatta R, Prasad TSK, Abhinand CS. Computational screening of phytocompounds from C. amboinicus identifies potential inhibitors of Influenza A (H3N2) virus by targeting hemagglutinin. J Biomol Struct Dyn. 2024; 


29.  

Hegde PS, Agni MB, Rai P, Upadhyay SS, Aravind A, Prasad TSK, et al. Supplementation of diet with astaxanthin and DHA prevents gestational and lactational undernourishment induced metabolic derangements in dams. 2024.

DOI


30.  

Gupta P, Goswami SG, Kumari G, Saravanakumar V, Bhargava N, Rai AB. Development of pathophysiologically relevant models of sickle cell disease and β-thalassemia for therapeutic studies. Nat Commun. 2024;

DOI


31.  

Daniel EA, Upadhyay S, Selvachithiram M, Pattabiramam S, Bhanu B, Sivaprakasam A, et al. Predictive metabolite signatures for risk of progression to active TB from QuantiFERON supernatants of household contacts of TB patients. Emerging Microbes & Infections. 2024; 

DOI


32.  

D’Cunha R, Aravind A, Bhaskar S, Mutalik SP, Mutalik S, Kalthur SG, et al. Enhanced cell survival in prepubertal testicular tissue cryopreserved with membrane lipids and antioxidants rich cryopreservation medium. Cell and Tissue Research. 2024; 

DOI


33.  

Aziz RA, Ramesh P, Suchithra KV, Stothard P, Narayana VK, Raghu SV. Comprehensive insights into the impact of bacterial indole-3-acetic acid on sensory preferences in Drosophila melanogaster. Sci Rep. 2024; 

DOI


34.  

Aravind A, Mathew RT, Kuruba L, Vijayakumar M, Prasad TSK, et al. Proteomic analysis of peripheral blood mononuclear cells from OSCC patients reveals potential immune checkpoints to enable personalized treatment. Molecular Omics. 2024; 

DOI


35.  

Krishnan D, Babu S, Raju R, Veettil MV, Prasad TS, Abhinand CS. Epstein–Barr Virus: Human Interactome Reveals New Molecular Insights into Viral Pathogenesis for Potential Therapeutics and Antiviral Drug Discovery. OMICS: A Journal of Integrative Biology. 2024;

DOI


36.  

Varghese B, Babu S, Jala A, Das P, Raju R, Borkar RM, Adela R. Integrative placental multi-omics analysis reveals perturbed pathways and potential prognostic biomarkers in gestational hypertension. Archives of Medical Research. 2024;
 

DOI


37.  

Banjan B, Krishnan D, Koshy AJ, Soman S, Leelamma A, Raju R, Revikumar A. In-silico screening and identification of potential drug-like compounds for dengue-associated thrombocytopenia from Carica papaya leaf extracts. Journal of Biomolecular Structure and Dynamics. 2024 Jul 23;42(11):5963-81.

DOI


38.  

Shastry RP, Abhinand CS. Targeting the Pseudomonas aeruginosa quorum sensing system to inhibit virulence factors and eradicate biofilm formation using AHL-analogue phytochemicals. Journal of Biomolecular Structure and Dynamics. 2024; DOI


1.  

Vijayakumar P, Mishra A, Pinto SM, Subbannayya Y, Sood R, Prasad TSK. Proteomics analysis of duck lung tissues in response to highly pathogenic avian influenza virus. Microorganisms. 2024; 

DOI


2.  

Vasishta S, Ammankallu S, Umakanth S, Prasad TSK, Joshi MB. DNA methyltransferase isoforms regulate endothelial cell exosome proteome composition. 2024.

DOI


3.  

Vasishta S, Ammankallu S, Poojary G, Gomes SM, Ganesh K, Umakanth S, et al. High glucose induces DNA methyltransferase 1 dependent epigenetic reprogramming of the endothelial exosome proteome in type 2 diabetes. International Journal of Biochemistry & Cell Biology. 2024; 

DOI


4.  

Usha T, Hemavathi KN, Goyal AK, Abhinand CS, Dhivya S, Cholarajan A, Joshi N, Babu D, Middha SK. Investigating emodin derivatives against SARS-CoV-2 found in medicinal herbs. Kuwait Journal of Science. 2024;

DOI


5.  

Thomas SD, Vijayakumar K, John L, Krishnan D, Rehman N, Revikumar A. Machine learning strategies in microRNA research. 2024;

DOI


6.  

Suchitha GP, Devasahayam Arokia Balaya R, Prasad TK, Dagamajalu S. A signaling network map of Lipoxin (LXA4): an anti-inflammatory molecule. Inflammation Research. 2024;

DOI


7.  

Suchitha GP, Jaikanth C, Saptami K, George M, Prasad TSK, Raju R. Cisplatin and Procaterol combination in gastric cancer? Targeting checkpoint kinase 1 (CHK1) for cancer drug discovery and repurposing by an integrated computational and experimental approaches. OMICS. 2024;

DOI


8.  

Suchitha GP, Dagamajalu S, Prasad TSK, Rex DAB. A comprehensive network map of Interleukin-26 signaling pathway. J Interferon Cytokine Res. 2024; 

DOI


9.  

Singh I, Hoti SL, Chauhan N, Joshi RK, Prasad TSK, Sarikhani M. Immunomodulation of streptozotocin-induced Type 1 Diabetes Mellitus in mouse model by Macrophage Migration Inhibitory Factor-2 (MIF-2) homologue of human lymphatic filarial parasite, Wuchereria bancrofti. 2024.

DOI


10.  

Singh I, Anagha A, Kotimoole CN, Modi PK, Prasad TSK, Hoti SL. Unpacking immune modulation as a site of therapeutics innovation for nematode parasite Wuchereria bancrofti. 2024.

DOI


11.  

Shaji V, Dagamajalu S, Sanjeev D, George M, Kanekar S, Prasad G. Deciphering the receptor-mediated signaling pathways of Interleukin-19 and Interleukin-20. J Interferon Cytokine Res. 2024; 

DOI


12.  

Shaikh SB, Rex DAB, Dagamajalu S, Bhandary YP, Unwalla H, Prasad TSK, et al. A signaling pathway map of plasminogen activator inhibitor 1 (PAI 1/SERPINE 1): a review of an innovative frontier in molecular aging and cellular senescence. Cell Communication and Signaling. 2024;

DOI


13.  

Devasahayam Arokia Balaya R, Palollathil A, Kumar ST, Chandrasekaran J, Upadhyay SS, Parate SS, Sajida M, Karthikkeyan G, Prasad TS. Role of Hemigraphis alternata in wound healing: metabolomic profiling and molecular insights into mechanisms. Scientific Reports. 2024;  

DOI


14.  

Ramesh P, Nisar M, Ammankallu S, Babu S, Nandakumar R, Abhinand CS, Prasad TS, Codi JA, Raju R. Delineating protein biomarkers for gastric cancers: A catalogue of mass spectrometry-based markers and assessment of their suitability for targeted proteomics applications. Journal of Proteomics. 2024

DOI


15.  

Priyanka P, Gopalakrishnan AP, Nisar M, Shivamurthy PB, George M, John L. A global phosphosite-correlated network map of Thousand And One Kinase 1 (TAOK1. Int J Biochem Cell Biol. 2024;

DOI


16.  

Pooja YT, Nair AS, D’silva S, Aravind A, Mallya S, Soman SP. Neutrophils display distinct post-translational modifications in response to varied pathological stimuli. Int Immunopharmacol. 2024; 

DOI


17.  

Parate SS, Upadhyay SS, Amrutha S, Karthikkeyan G, Pervaje R, Abhinand CS. Comparative metabolomics and network pharmacology analysis reveals shared neuroprotective mechanisms of Bacopa monnieri (L.) Wettst and Centella asiatica (L.) Urb. Mol Neurobiol. 2024;

DOI


18.  

Palollathil A, Babu S, Abhinand CS, Mathew RT, Vijayakumar M, Prasad TS. Proteomic profiling of oral squamous cell carcinoma tissues altered-related proteins: implications for personalized therapy. Expert review of proteomics. DOI


19.  

Pai AA, Upadhyay SS, Thattai AKS, Parate SS, Illangeswaran RST, Renji RM. Global plasma metabolomic profiling reveals dysregulated lipid metabolism in patients with hepatic sinusoidal obstruction syndrome - a pilot biomarker study. Transplant Cell Ther. 2024; 

DOI


20.  

Munjal A, Rex DA, Prasad TK, Mukherjee S, Pati S, Singh S. Mass spectrometric identification of the secretome of Plasmodium falciparum merozoites to provide novel candidates for vaccine development pipeline. Authorea Preprints. 2024;

DOI


21.  

Munjal A, Rex DAB, Garg B, Prasad TSK, Mishra SK, Malhotra Y. Mass spectrometric and Artificial Intelligence-based identification of the secretome of Plasmodium falciparum merozoites to provide novel candidates for vaccine development pipeline. Proteomics Clin Appl. 2024;

DOI


22.  

Mishra D, Shekhar S, Subba P, Prasad TSK, Chakraborty S, Chakraborty N. Wheat TaNACα18 functions as a positive regulator of high-temperature adaptive responses and improves cell defense machinery. Plant J. 2024; 

DOI


23.  

Mahin A, Soman SP, Modi PK, Raju R, Keshava Prasad TS, Abhinand CS. Meta-analysis of the serum/plasma proteome identifies significant associations between COVID-19 with Alzheimer’s/Parkinson’s diseases. Journal of neurovirology. 2024;

In press


24.  

Mahin A, Chikmagalur Ravindra S, Ramesh P, Naik P, Raju R, Keshava Prasad TS, Abhinand CS. Unveiling Actin Cytoskeleton Role in Mediating Chikungunya-Associated Arthritis: An Integrative Proteome–Metabolome Study. Vector-Borne and Zoonotic Diseases. 2024;

DOI


25.  

Kunnath AN, Parker SK, Crasta DN, Kunhiraman JP, Madhvacharya VV, Kumari S, Nayak G, Lakshmi RV, Modi PK, Prasad TS, Kumar A. Metformin augments major cytoplasmic organization except for spindle organization in oocytes cultured under hyperglycemic and hyperlipidemic conditions: An in vitro study. Toxicology and Applied Pharmacology. 2024

DOI


26.  

Kotimoole CN, Ramya VK, Kaur P, Reiling N, Shandil RK, Narayanan S. Discovery of species-specific proteotypic peptides to establish a spectral library platform for the identification of non-tuberculosis mycobacteria from mass spectrometry-based proteomics. J Proteome Res. 2024; 

DOI


27.  

Hemavathi KN, Skariyachan S, Raju R, Prasad TSK, Abhinand CS. Computational screening of potential anti-inflammatory leads from Jeevaneeya Rasayana plants targeting COX-2 and 5-LOX by molecular docking and dynamic simulation approaches. Comput Biol Med. 2024; 

DOI


28.  

Hemavathi KN, Middha SK, Raju R, Pilankatta R, Prasad TSK, Abhinand CS. Computational screening of phytocompounds from C. amboinicus identifies potential inhibitors of Influenza A (H3N2) virus by targeting hemagglutinin. J Biomol Struct Dyn. 2024; 


29.  

Hegde PS, Agni MB, Rai P, Upadhyay SS, Aravind A, Prasad TSK, et al. Supplementation of diet with astaxanthin and DHA prevents gestational and lactational undernourishment induced metabolic derangements in dams. 2024.

DOI


30.  

Gupta P, Goswami SG, Kumari G, Saravanakumar V, Bhargava N, Rai AB. Development of pathophysiologically relevant models of sickle cell disease and β-thalassemia for therapeutic studies. Nat Commun. 2024;

DOI


31.  

Daniel EA, Upadhyay S, Selvachithiram M, Pattabiramam S, Bhanu B, Sivaprakasam A, et al. Predictive metabolite signatures for risk of progression to active TB from QuantiFERON supernatants of household contacts of TB patients. Emerging Microbes & Infections. 2024; 

DOI


32.  

D’Cunha R, Aravind A, Bhaskar S, Mutalik SP, Mutalik S, Kalthur SG, et al. Enhanced cell survival in prepubertal testicular tissue cryopreserved with membrane lipids and antioxidants rich cryopreservation medium. Cell and Tissue Research. 2024; 

DOI


33.  

Aziz RA, Ramesh P, Suchithra KV, Stothard P, Narayana VK, Raghu SV. Comprehensive insights into the impact of bacterial indole-3-acetic acid on sensory preferences in Drosophila melanogaster. Sci Rep. 2024; 

DOI


34.  

Aravind A, Mathew RT, Kuruba L, Vijayakumar M, Prasad TSK, et al. Proteomic analysis of peripheral blood mononuclear cells from OSCC patients reveals potential immune checkpoints to enable personalized treatment. Molecular Omics. 2024; 

DOI


35.  

Krishnan D, Babu S, Raju R, Veettil MV, Prasad TS, Abhinand CS. Epstein–Barr Virus: Human Interactome Reveals New Molecular Insights into Viral Pathogenesis for Potential Therapeutics and Antiviral Drug Discovery. OMICS: A Journal of Integrative Biology. 2024;

DOI


36.  

Varghese B, Babu S, Jala A, Das P, Raju R, Borkar RM, Adela R. Integrative placental multi-omics analysis reveals perturbed pathways and potential prognostic biomarkers in gestational hypertension. Archives of Medical Research. 2024;
 

DOI


37.  

Banjan B, Krishnan D, Koshy AJ, Soman S, Leelamma A, Raju R, Revikumar A. In-silico screening and identification of potential drug-like compounds for dengue-associated thrombocytopenia from Carica papaya leaf extracts. Journal of Biomolecular Structure and Dynamics. 2024 Jul 23;42(11):5963-81.

DOI


38.  

Shastry RP, Abhinand CS. Targeting the Pseudomonas aeruginosa quorum sensing system to inhibit virulence factors and eradicate biofilm formation using AHL-analogue phytochemicals. Journal of Biomolecular Structure and Dynamics. 2024; DOI


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